Structural Speciation of Hybrid Ti(IV)-Chrysin Systems-Biological Profiling and Antibacterial, Anti-Inflammatory, and Tissue-Specific Anticancer Activity.

Sevasti Matsia, Georgios Lazopoulos, Antonios Hatzidimitriou, Athanasios Salifoglou

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Physicochemical Characterization and Larvicidal Activity of a Rutin-Zn Material againstACS omega · 2026
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Authors and funding

4 authors.

Sevasti MatsiaLaboratory of Inorganic Chemistry and Advanced Materials, School of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0003-3777-9815

Georgios LazopoulosLaboratory of Inorganic Chemistry and Advanced Materials, School of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-3335-5751

Antonios HatzidimitriouLaboratory of Inorganic Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-6237-126X

Athanasios SalifoglouLaboratory of Inorganic Chemistry and Advanced Materials, School of Chemical Engineering, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-1822-7989

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal-organic compounds, and especially those containing well-known antioxidant natural flavonoids (Chrysin, Chr) and metal ions (Ti(IV)), attract keen interest for their potential biological activity nutritionally and pharmacologically. To that end, chemical reactivity profiling in binary/ternary systems was investigated synthetically, revealing unique structural correlations between mononuclear (Ti(IV)-Chr) and tetranuclear assemblies (Ti(IV)-Chr-phen). Chemical profiling involved physicochemical characterization through elemental analysis, FT-IR, UV-Visible, 1D-2D NMR, ESI-MS spectrometry, solid-state luminescence, and X-ray crystallography, with theoretical work on intra(inter)molecular interactions of 3D assemblies pursued through Hirshfeld analysis and BVS calculations. An in-depth study of their chemical reactivity shed light onto specific structural properties in the solid-state and in solution, while concurrently exemplifying quenching behavior due to their distinct flavonoid pattern. In the framework of biological activity, the materials were investigated for their antibacterial properties toward Gram(-)-

Indexed as

Anti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic AgentsFlavonoidsCell Line, TumorEscherichia coliHumansMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsAnti-Inflammatory AgentsAntineoplastic AgentschrysinFlavonoidsantibacterialanticancerchrysincoordination chemistryflavonoidinflammationin vitro investigationtitanium

Identifiers

PMID41011562

DOI10.3390/molecules30183667

PMCPMC12472876

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.