Evidence map›Paper›PMID 41011379›Full record

ArticleMicroorganisms2025

Identification of Reassortant Mammalian Orthoreovirus Strains in European Hedgehogs (

Tiziana Trogu, Maya Carrera, Clara Tolini, Ambra Nucci, Sabrina Canziani, Guido Grilli, Maria Cristina Rapi, Sara Manfredini, Silva Rubini, Davide Lelli and 5 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tiziana TroguVirology Department, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.
Maya CarreraVirology Department, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.ORCID 0000-0003-0843-7728
Clara ToliniVirology Department, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.ORCID 0000-0002-4527-0210
Ambra NucciVirology Department, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.
Sabrina CanzianiVirology Department, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.
Guido GrilliDepartment of Veterinary Medicine and Animal Sciences, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.ORCID 0000-0001-6157-7258
Maria Cristina RapiDepartment of Veterinary Medicine and Animal Sciences, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.ORCID 0009-0007-1496-5195
Sara ManfrediniDepartment of Veterinary Medicine and Animal Sciences, University of Milan, Via dell'Università 6, 26900 Lodi, Italy.
Silva RubiniDiagnostic Laboratory of Ferrara, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Modena, 483, Cassana, 44044 Ferrara, Italy.ORCID 0000-0002-1764-5804
Davide LelliVirology Department, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.ORCID 0000-0002-5775-6058
Valentina CartaGenomic Analysis Laboratory, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.ORCID 0000-0003-1054-1348
Cristina BertasioGenomic Analysis Laboratory, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.ORCID 0000-0002-1082-982X
Enrica SozziVirology Department, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.ORCID 0000-0002-0144-1217
Antonio LavazzaVirology Department, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.ORCID 0000-0002-7646-3592
Ana MorenoVirology Department, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna-IZSLER, Via Bianchi, 9, 25124 Brescia, Italy.ORCID 0000-0002-8497-9708

Funding

Italian Health Ministry, CCM_SURVEID, Pilot Study For Surveillance Of Potential Emerging Infectious Disease (Eids) Threats Of Viral Origin Using A Diagnostic Platform Based On Next-Generation Metagenomic Sequencing (Mngs) B93C22001210001NextGeneration EU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseas-es PE00000007, INF-ACT
6 · The paper itself

Abstract

Thanks to its ethological and physiological characteristics, the hedgehog is a synanthropic species of particular importance for the maintenance and possible spread of pathogens, some of which are zoonotic. Among these, we can include the mammalian orthoreovirus (MRV), which is characterized by respiratory, gastrointestinal, and neurological symptoms in both animals and humans. MRV is characterized by a high capacity for genetic reassortment and intragenic rearrangement, and the ability to infect a wide range of mammals. This work aims to investigate the presence of MRVs and its genomic characterization in hedgehogs. During the two-year period from 2022 to 2023, the intestine and lungs were collected from 293 hedgehogs and subjected to real-time PCR to detect the L1 gene. Positive samples were subjected to a typing RT-PCR targeting a portion of the S1 gene and then to sequencing. A total of 38 hedgehogs tested positive by real-time PCR (

Indexed as

genomic characterizationhedgehogsItalymammalian orthoreovirusreassortment

Identifiers

PMID41011379
PMCPMC12473063

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.