Evidence map›Paper›PMID 41011364›Full record

ArticleMicroorganisms2025

Incidence of Acanthamoeba Keratitis in Switzerland.

Frank Blaser, Felix Grimm, Philipp B Baenninger, Zisis Gatzioufas, Michael A Thiel, Moreno Menghini, Beatrice E Frueh, Konrad Muehlethaler, Marco Alder, Kattayoon Hashemi and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Frank BlaserDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.ORCID 0009-0000-9807-9623
Felix GrimmInstitute of Parasitology, University of Zurich, 8006 Zurich, Switzerland.
Philipp B BaenningerDepartment of Ophthalmology, Cantonal Hospital Winterthur, 8400 Winterthur, Switzerland.
Zisis GatzioufasDepartment of Ophthalmology, University Hospital Basel, 4056 Basel, Switzerland.
Michael A ThielDepartment of Ophthalmology, Cantonal Hospital Lucerne, 6000 Lucerne, Switzerland.ORCID 0000-0002-0135-2468
Moreno MenghiniDepartment of Ophthalmology, Institute of Clinical Neurosciences of Southern Switzerland (INSI), Ente Ospedaliero Cantonale (EOC), 6900 Lugano, Switzerland.
Beatrice E FruehDepartment of Ophthalmology, Bern University Hospital, Inselspital, University of Bern, 3010 Bern, Switzerland.
Konrad MuehlethalerInstitute for Infectious Diseases, University of Bern, 3012 Bern, Switzerland.
Marco AlderDepartment of Ophthalmology, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.
Kattayoon HashemiDepartment of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, 1004 Lausanne, Switzerland.
René BrouilletInstitute of Microbiology, University of Lausanne, 1015 Lausanne, Switzerland.
Horace MassaDepartment of Ophthalmology, University Hospital Geneva, University of Geneva, 1205 Geneva, Switzerland.ORCID 0000-0001-5025-3856
Manolito L FingerDepartment of Ophthalmology, Cantonal Hospital Fribourg, 1752 Fribourg, Switzerland.
Christoph TappeinerDepartment of Ophthalmology, Pallas Klinik, 4600 Olten, Switzerland.ORCID 0000-0001-6907-1112
Anthia PapazoglouDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-9768-8301
Florentina Joyce FreibergDepartment of Ophthalmology, City Hospital Triemli, 8055 Zurich, Switzerland.
Gilbert GreubService of Microbiology, University Hospital of Lausanne, 1005 Lausanne, Switzerland.ORCID 0000-0001-9529-3317
Daniel BarthelmesDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0002-5431-4991
Sandrine A ZweifelDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0001-7431-1774
Sadiq SaidDepartment of Ophthalmology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.ORCID 0000-0003-2037-4766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite rising global reports of Acanthamoeba keratitis (AK), the incidence of AK in Switzerland remains unknown. This investigator-initiated, retrospective, multicenter study assessed the nationwide incidence of PCR- and/or culture-positive Acanthamoeba results from January 2010 to December 2023. Data were collected from all tertiary care and large ophthalmological facilities in Switzerland, fully anonymized, and aggregated by month and year. We considered all corneal scraping results, whereby the detection method was specific to local standards. We identified 271 PCR- or culture-positive Acanthamoeba cases over 14 years. Applying the population data from the Federal Statistical Office in Switzerland, this corresponds to a mean incidence of 2.29 cases per million people annually. Infections were most common in summer (87 cases, 32.1%), followed by autumn (74 cases, 27.3%), spring (60 cases, 22.1%), and winter (50 cases, 18.5%). We found no significant change in incidence across the investigated period,

Indexed as

acanthamoeba keratitisepidemiologyincidenceinfectious keratitisSwitzerland

Identifiers

PMID41011364
PMCPMC12471702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.