Evidence map›Paper›PMID 41011314›Full record

ReviewMicroorganisms2025

Microbial Landscapes of the Gut-Biliary Axis: Implications for Benign and Malignant Biliary Tract Diseases.

David Meacci, Angelo Bruni, Alice Cocquio, Giuseppe Dell'Anna, Francesco Vito Mandarino, Giovanni Marasco, Paolo Cecinato, Giovanni Barbara, Rocco Maurizio Zagari

Abstract readReview
In one paragraph

Review in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Microbial dysbiosis in cholangiocarcinoma.Frontiers in microbiology · 2026
    Review
  5. Involvement of bile acids in cholangiocarcinoma progressionWorld journal of gastrointestinal oncology · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David MeacciDepartment of Medical and Surgical Sciences, Universitaria di Bologna, 40126 Bologna, Italy.
Angelo BruniDepartment of Medical and Surgical Sciences, Universitaria di Bologna, 40126 Bologna, Italy.ORCID 0009-0002-0895-1225
Alice CocquioDepartment of Medical and Surgical Sciences, Universitaria di Bologna, 40126 Bologna, Italy.
Giuseppe Dell'AnnaGastroenterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Hospital, 20132 Milan, Italy.ORCID 0000-0002-9395-5468
Francesco Vito MandarinoGastroenterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Hospital, 20132 Milan, Italy.ORCID 0000-0002-9931-7221
Giovanni MarascoDepartment of Medical and Surgical Sciences, Universitaria di Bologna, 40126 Bologna, Italy.ORCID 0000-0001-7167-8773
Paolo CecinatoGastroenterology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-1870-5952
Giovanni BarbaraDepartment of Medical and Surgical Sciences, Universitaria di Bologna, 40126 Bologna, Italy.
Rocco Maurizio ZagariDepartment of Medical and Surgical Sciences, Universitaria di Bologna, 40126 Bologna, Italy.ORCID 0000-0001-9949-8619

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Next-generation sequencing has overturned the dogma of biliary sterility, revealing low-biomass microbiota along the gut-biliary axis with metabolic and immunologic effects. This review synthesizes evidence on composition, function, and routes of colonization across benign and malignant disease. In cholelithiasis,

Indexed as

bile acidsbiliary microbiomeoncobiome

Identifiers

PMID41011314
PMCPMC12472106

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.