Comprehensive Identification and Mechanistic Evaluation of Novel DHODH Inhibitors as Potent Broad-Spectrum Antiviral Agents.

Chao Zhang, Shiyang Sun, Huiru Xie, Yongzhao Ding, Chun Hu, Jialin Guo, Junhai Xiao

Abstract read

In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chao ZhangState Key Laboratory of National Security Specially Needed Medicines, Beijing 100039, China.ORCID 0000-0002-0166-7873

Shiyang SunState Key Laboratory of National Security Specially Needed Medicines, Beijing 100039, China.

Huiru XieState Key Laboratory of National Security Specially Needed Medicines, Beijing 100039, China.

Yongzhao DingState Key Laboratory of National Security Specially Needed Medicines, Beijing 100039, China.

Chun HuKey Laboratory of Structure-Based Drug Design Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.ORCID 0000-0003-2919-2870

Jialin GuoState Key Laboratory of National Security Specially Needed Medicines, Beijing 100039, China.

Junhai XiaoState Key Laboratory of National Security Specially Needed Medicines, Beijing 100039, China.

Funding

National Natural Science Foundation of China 82404415Postdoctoral Research Foundation of China 2023M744315

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

broad-spectrum antiviral agentsdihydroorotate dehydrogenaseinfluenza virusMD simulationSARS-CoV-2

Identifiers

PMID41011283

DOI10.3390/ph18091416

PMCPMC12472551

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.