Promising Norlabdane-Heterocyclic Hybrids: Synthesis, Structural Characterization and Antimicrobial Activity Evaluation.

Lidia Lungu, Alexandru Ciocarlan, Ionel I Mangalagiu, Aculina Aricu

Abstract readReview

In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lidia LunguInstitute of Chemistry, Moldova State University, 3 Academiei Street, MD-2028 Chisinau, Moldova.ORCID 0000-0002-9495-2621

Alexandru CiocarlanInstitute of Chemistry, Moldova State University, 3 Academiei Street, MD-2028 Chisinau, Moldova.

Ionel I MangalagiuFaculty of Chemistry, Alexandru Ioan Cuza University of Iasi, 11 Carol Bd., 700506 Iasi, Romania.ORCID 0000-0002-4632-5076

Aculina AricuInstitute of Chemistry, Moldova State University, 3 Academiei Street, MD-2028 Chisinau, Moldova.

Funding

The Institutional Research Program of the Moldova State University (MSU) 010601

6 · The paper itself

Abstract

The terpeno-heterocyclic molecular hybrids are a new and promising class of modern organic and medicinal chemistry, because their molecules exhibit high and selective biological activity, natural origins, and good biocompatibility, and, usually, they are less toxic. The reported norlabdane-heterocyclic hybrids were synthesized by classical and new, original, and environmentally friendly methods, which include coupling reactions of norlabdane derivatives (such as carboxylic acids, acyl chlorides, or bromides) with individual heterocyclic compounds, as well as heterocyclization reactions of certain norlabdane intermediates like hydrazides, thiosemicarbazones, or hydrazinecarbothioamides. The aforementioned norlabdanes were derived from (+)-sclareolide

Indexed as

1,2,4-triazoles1,3,4-oxadiazoles1,3,4-thiadiazoles1,3-benzimidazoles1,3-benzothiazoles1,3-thiazolesdiazinesnorlabdane-heterocyclic hybrids

Identifiers

PMID41011278

DOI10.3390/ph18091411

PMCPMC12472533

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.