Evidence map›Paper›PMID 41011249›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

Click-to-Release for Controlled Immune Cell Activation: Tumor-Targeted Unmasking of an IL12 Prodrug.

Martijn H den Brok, Kim E de Roode, Luc H M Zijlmans, Laurens H J Kleijn, Marleen H M E van Stevendaal, Ron M Versteegen, Lieke W M Wouters, Raffaella Rossin, Marc S Robillard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. RSC chemical biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martijn H den BrokTagworks Pharmaceuticals, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0002-2368-0411
Kim E de RoodeTagworks Pharmaceuticals, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.ORCID 0009-0009-6985-3507
Luc H M ZijlmansTagworks Pharmaceuticals, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
Laurens H J KleijnTagworks Pharmaceuticals, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
Marleen H M E van StevendaalTagworks Pharmaceuticals, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
Ron M VersteegenSyMO-Chem, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.ORCID 0000-0002-0832-5120
Lieke W M WoutersTagworks Pharmaceuticals, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.ORCID 0009-0007-0397-5443
Raffaella RossinTagworks Pharmaceuticals, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
Marc S RobillardTagworks Pharmaceuticals, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.ORCID 0000-0002-3690-2087

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

bioorthogonalcancerclickclick-to-releasecytokineIL12immunotherapymaskingpolyethyleneglycoltetrazinetrans-cycloocteneunmasking

Identifiers

PMID41011249
PMCPMC12472795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.