Evidence map›Paper›PMID 41010452›Full record

ArticleNutrients2025

Vitamin D Genetics Beyond Serum 25(OH)D:

Dariusz Larysz, Remigiusz Recław, Aleksandra Suchanecka, Wojciech Dziurawiec, Rafał Tkacz, Aleksandra Strońska-Pluta, Krzysztof Chmielowiec, Anna Grzywacz, Jolanta Chmielowiec

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In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dariusz LaryszDepartment of Trauma and Orthopaedic Surgery, 109th Military Hospital with Polyclinic, Ministry of National Defense, ul. Ksiedza Piotra Skargi 9/11, 71-422 Szczecin, Poland.ORCID 0009-0007-4267-2250
Remigiusz RecławIndependent Laboratory of Genetics and Behavioral Epigenetics, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.ORCID 0009-0004-7841-821X
Aleksandra SuchaneckaIndependent Laboratory of Genetics and Behavioral Epigenetics, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.ORCID 0000-0002-7137-1429
Wojciech DziurawiecDepartment of Trauma and Orthopaedic Surgery, 109th Military Hospital with Polyclinic, Ministry of National Defense, ul. Ksiedza Piotra Skargi 9/11, 71-422 Szczecin, Poland.ORCID 0009-0001-6011-9383
Rafał TkaczDepartment of Trauma and Orthopaedic Surgery, 109th Military Hospital with Polyclinic, Ministry of National Defense, ul. Ksiedza Piotra Skargi 9/11, 71-422 Szczecin, Poland.ORCID 0009-0001-7091-6829
Aleksandra Strońska-PlutaIndependent Laboratory of Genetics and Behavioral Epigenetics, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.ORCID 0000-0001-6564-2141
Krzysztof ChmielowiecDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Gora, Poland.ORCID 0000-0003-4254-5466
Anna GrzywaczIndependent Laboratory of Genetics and Behavioral Epigenetics, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 St., 70-111 Szczecin, Poland.ORCID 0000-0002-2633-520X
Jolanta ChmielowiecDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Gora, Poland.ORCID 0000-0003-3285-5313

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D receptor (VDR) polymorphisms may influence immune regulation and musculoskeletal health, but their perioperative role is not well understood. This study investigated the rs2228570 (

methodsWe genotyped 300 orthopedic patients and 200 healthy controls using real-time PCR. Regression models in patients adjusted for age and body mass index (BMI) examined associations between rs2228570 genotypes and laboratory as well as clinical outcomes.

resultsThe CC genotype (homozygous cytosine) was associated with higher white blood cell count (β = 0.52,

conclusionsThe rs2228570 polymorphism in the VDR gene is associated with distinct perioperative inflammatory, hematologic, and patient-reported profiles. These findings support the potential clinical utility of VDR genotyping, in combination with routine laboratory tests, to refine perioperative risk stratification and guide personalized rehabilitation in orthopedic patients.

Indexed as

InflammationOrthopedic ProceduresPolymorphism, Single NucleotideQuality of LifeReceptors, CalcitriolVitamin DAdultAgedCase-Control StudiesFemaleGenotypeHumansMaleMiddle Aged25-hydroxyvitamin DReceptors, CalcitriolVDR protein, humanVitamin Dblood biochemical markersFokI polymorphismorthopedic surgeryquality of lifers2228570vitamin D receptor (VDR)

Identifiers

PMID41010452
PMCPMC12472729

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.