ArticleLife (Basel, Switzerland)2025
Inflammatory Profile and Risk of Hypertension in Infants Following Coarctation of the Aorta Repair: The Role of IL-6/TNF-α Ratio.
Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Correlates of Recoarctation After Repair in Pediatric Patients with Aortic Coarctation: A Real-World Descriptive Study.Journal of clinical medicine · 2026Article
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7 authors.
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Abstract
backgroundDespite anatomically successful surgical correction, postoperative hypertension remains a significant concern in patients with coarctation of the aorta, even when repair is performed during infancy. Inflammation and neurohormonal activation have been proposed as contributing mechanisms.
objectiveTo investigate the association between preoperative inflammatory biomarkers-specifically the interleukin-6 (IL-6) to tumor necrosis factor-alpha (TNF-α) ratio-and the development of hypertension in patients with successful isolated coarctation of the aorta repair under one year of age.
methodsThis observational study included 42 infants with isolated CoA. Clinical, echocardiographic, and biochemical parameters were analyzed. Preoperative plasma levels of IL-6, TNF-α, von Willebrand factor (vWF), and renin were measured. Patients were classified based on hypertensive status at 2-year follow-up. Univariate and multivariate logistic regression analyses were performed to identify predictors of postoperative hypertension.
resultsHypertension was diagnosed in 16 out of 41 patients (39%) at follow-up. A preoperative IL-6/TNF-α ratio > 2 was an independent predictor in multivariate analysis for postoperative HT (OR = 6.1, 95% CI = 6.23-9.31,
conclusionsIn this small single-center cohort, an elevated IL-6/TNF-α ratio was associated with postoperative hypertension after coarctation repair. These exploratory findings should be considered hypothesis-generating and warrant confirmation in larger, multicenter studies.
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