Evidence map›Paper›PMID 41010415›Full record

ArticleLife (Basel, Switzerland)2025

Interpreting Deep Neural Networks in Diabetic Retinopathy Grading: A Comparison with Human Decision Criteria.

Sangeeta Biswas, Md Ahanaf Arif Khan, Md Hasnain Ali, Johan Rohdin, Subrata Pramanik, Md Iqbal Aziz Khan, Sanjoy Kumar Chakravarty, Bimal Kumar Pramanik

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sangeeta BiswasFaculty of Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.ORCID 0000-0001-6322-8836
Md Ahanaf Arif KhanFaculty of Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.ORCID 0009-0005-6098-8318
Md Hasnain AliFaculty of Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.ORCID 0009-0001-2367-9517
Johan RohdinFaculty of Information Technology, Brno University of Technology, 61200 Brno, Czech Republic.ORCID 0000-0003-0978-2064
Subrata PramanikFaculty of Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.ORCID 0009-0002-1985-5044
Md Iqbal Aziz KhanFaculty of Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.ORCID 0009-0005-2910-5177
Sanjoy Kumar ChakravartyFaculty of Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.ORCID 0009-0004-1225-4208
Bimal Kumar PramanikFaculty of Engineering, University of Rajshahi, Rajshahi 6205, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) causes visual impairment and blindness in millions of diabetic patients globally. Fundus image-based Automatic Diabetic Retinopathy Classifiers (ADRCs) can ensure regular retina checkups for many diabetic patients and reduce the burden on the limited number of retina experts by referring only those patients who require their attention. Over the last decade, numerous deep neural network-based algorithms have been proposed for ADRCs to distinguish the severity levels of DR. However, it has not been investigated whether DNN-based ADRCs consider the same criteria as human retina professionals (HRPs), i.e., whether they follow the same grading scale when making decisions about the severity level of DR, which may put the reliability of ADRCs into question. In this study, we investigated this issue by experimenting on publicly available datasets using MobileNet-based ADRCs and analyzing the output of the ADRCs using two eXplainable artificial intelligence (XAI) techniques named Gradient-weighted Class Activation Map (Grad-CAM) and Integrated Gradients (IG).

Indexed as

deep neural networkd iabetic retinopathy classificationfundus imageGrad-CAMintegrated gradients

Identifiers

PMID41010415
PMCPMC12472159

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.