Evidence map›Paper›PMID 41010294›Full record

ArticleLife (Basel, Switzerland)2025

Real-World Use of Extended Half-Life Factor IX in Children with Haemophilia B.

Athina Dettoraki, Aikaterini Michalopoulou, Stefanos Saslis, Konstantina Dakou, Ioanna Stamati, Sotiria Thymianou, Zoey Kapsimali, Olympia Papakonstantinou, Helen Pergantou

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Extended Half-Life Factor Concentrates in Haemophilia Treatment.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Athina DettorakiHaemophilia Centre, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 1 Thivon and Papadiamantopoulou Str., 115 27 Athens, Greece.ORCID 0000-0001-8232-3767
Aikaterini MichalopoulouHaemophilia Centre, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 1 Thivon and Papadiamantopoulou Str., 115 27 Athens, Greece.
Stefanos SaslisHaemophilia Centre, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 1 Thivon and Papadiamantopoulou Str., 115 27 Athens, Greece.
Konstantina DakouHaemophilia Centre, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 1 Thivon and Papadiamantopoulou Str., 115 27 Athens, Greece.ORCID 0000-0001-7399-4884
Ioanna StamatiHaemophilia Centre, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 1 Thivon and Papadiamantopoulou Str., 115 27 Athens, Greece.
Sotiria ThymianouHaemophilia Centre, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 1 Thivon and Papadiamantopoulou Str., 115 27 Athens, Greece.
Zoey KapsimaliHaemophilia Centre, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 1 Thivon and Papadiamantopoulou Str., 115 27 Athens, Greece.
Olympia Papakonstantinou2nd Department of Radiology, National and Kapodistrian University of Athens, "Attikon" University Hospital of Athens, 1 Rimini Str., Chaidari, 124 62 Athens, Greece.ORCID 0000-0003-0331-207X
Helen PergantouHaemophilia Centre, Haemostasis and Thrombosis Unit, "Aghia Sophia" Children's Hospital, 1 Thivon and Papadiamantopoulou Str., 115 27 Athens, Greece.ORCID 0000-0002-1792-0597

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Limited studies have reported data on the real-world clinical use of extended half-life (EHL) IX products in children and adolescents with haemophilia B, also referred to as people with haemophilia B (PWHB). Aim To examine the real-life experience with EHL factor IX products in PWHB regarding the clinical experience with standard half-life products (SHL). Methods A retrospective review of medical records of PWHB who have been prescribed EHL IX factor concentrates was conducted. Results Fourteen male PWHB were enrolled in the study, all with severe bleeding phenotypes being on prophylaxis (1-6 years old:

Indexed as

annual bleeding rateannual joint bleeding rateextended half-life factor concentrateshaemophiliaprophylaxisstandard half-life factor concentrates

Identifiers

PMID41010294
PMCPMC12470991

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.