Evidence map›Paper›PMID 41010139›Full record

ReviewMaterials (Basel, Switzerland)2025

Recent Advances in pH-Responsive Liposomes: Lessons Learnt and New Directions in Nanomedicine Development.

Antonia Georgia Tsirogianni, Maria Chountoulesi, Natassa Pippa

Abstract readReview
In one paragraph

Review in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Vaccine Adjuvants and Delivery Systems: A Comprehensive Review.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Antonia Georgia TsirogianniSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.
Maria ChountoulesiSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.
Natassa PippaSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece.ORCID 0000-0002-1197-9010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of pH-responsive liposomes represents a promising strategy for targeted drug delivery, enhancing therapeutic efficacy while minimizing toxicity and side effects. These innovative nanocarriers are typically synthesized via the thin film hydration method and can be further modified to exhibit stimuli-responsive behavior. pH-responsive liposomes are biocompatible, biodegradable, and capable of encapsulating both hydrophilic and hydrophobic drugs, increasing their versatility in drug delivery. In this mini-review, we explore the mechanism of action of pH-responsive liposomes, analyzing the factors that influence both their intracellular and extracellular behavior. Various formulations are examined, and their characteristics are compared to optimize therapeutic outcomes. Furthermore, we discuss the potential applications in anticancer therapy, in gene therapy, and in bacterial infections as vaccines and diagnostic agents.

Indexed as

acid microenvironmentanticancergene therapyliposomesphospholipidspH-responsivetriggered releasetumor targeting

Identifiers

PMID41010139
PMCPMC12471921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.