Evidence map›Paper›PMID 41010122›Full record

ReviewMaterials (Basel, Switzerland)2025

An Update Regarding the Use of Contemporary Dental Materials in Periodontal Regeneration.

Dragos Ioan Virvescu, Ovidiu-Sebastian Nicolaiciuc, Gabriel Rotundu, Florinel Cosmin Bida, Oana-Maria Butnaru, Zinovia Surlari, Mihaela Scurtu, Dana Gabriela Budala, Ionut Luchian

Abstract readReview
In one paragraph

Review in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dragos Ioan VirvescuDepartment of Dental Materials, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0005-6872-179X
Ovidiu-Sebastian NicolaiciucDepartment of Dental Technology, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Gabriel RotunduDepartment of Periodontology, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0000-2536-7667
Florinel Cosmin BidaDepartment of Complete Dentures, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0001-0319-0538
Oana-Maria ButnaruDepartment of Biophysics, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-7404-399X
Zinovia SurlariDepartment of Fixed Dentures, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0009-5914-2891
Mihaela ScurtuDepartment of Fixed Dentures, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Dana Gabriela BudalaDepartment of Complete Dentures, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0003-2312-6987
Ionut LuchianDepartment of Periodontology, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0003-0017-9672

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeriodontal regeneration has become a focal point in modern dental therapy, aiming to restore the form and function of lost periodontal structures. A literature search was conducted on the PubMed, Scopus, and Web of Science databases, focusing on studies published between 2000 and 2025 that addressed the clinical use of dental biomaterials in periodontal regeneration. Emphasis was placed on the use of bone grafts, guided tissue regeneration (GTR) membranes, enamel matrix derivatives, scaffolds, growth factors, and stem cell-based technologies. The review also outlines the limitations of current strategies, including unpredictable clinical responses, the rapid degradation of bioactive components, and variability in healing. Emerging directions, such as nanotechnology, gene-activated matrices, and 3D-printed scaffolds, are highlighted for their potential to improve predictability and personalization in periodontal therapy. This synthesis underscores both the progress and ongoing challenges in the field, emphasizing the need for continued research into material innovation and patient-specific solutions.

Indexed as

bone graftsdental biomaterialsenamel matrix derivativesgrowth factorsguided tissue regeneration (GTR)periodontal regenerationscaffoldsstem cells

Identifiers

PMID41010122
PMCPMC12472071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.