ReviewMaterials (Basel, Switzerland)2025
Endodontic Sealers and Innovations to Enhance Their Properties: A Current Review.
Review in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative efficacy of novel biomaterials versus traditional materials in the treatment of dental and pulpal diseases: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Intracanal adaptation and bond strength assessment of novel liquid/powder calcium silicate-based root canal sealer.Journal of clinical and experimental dentistry · 2026Article
- Bioceramic versus conventional endodontic sealers: An umbrella review.Journal of conservative dentistry and endodontics · 2026Review
- In Vitro Comparison of Void Formation Between Calcium Silicate-Based Sealers and AH Plus: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Review
- Effect of dentin pre-treatment with Bioglass F18 suspensions on surface characteristics and bond strength of endodontic sealers.Clinical oral investigations · 2026Article
- Adherence to endodontic treatment protocols in the clinical practice of Lithuanian dentists and endodontists-cross-sectional study.BMC oral health · 2026Article
- Article
- Epoxy resin-based sealers modified with clay nanoparticles: Evaluation of their physicochemical and mechanical properties.European journal of oral sciences · 2026Article
- Physicochemical Characterization and In Vitro Biocompatibility of Epoxy- and Silicone-Based Endodontic Materials.Materials (Basel, Switzerland) · 2026Article
- In Vitro Assessment of Osteogenic Modulation and Molecular Responses Induced by Contemporary Endodontic Sealers in MC3T3-E1 Pre-Osteoblasts.Dentistry journal · 2026Article
- Use of Bioceramic Sealers in Clinical Practice Among Dentists in Saudi Arabia: A Cross-Sectional Analysis.Cureus · 2026Article
- Modifications of Resorbable Root Canal Filling Materials for Primary Teeth: A Systematic Review.Materials (Basel, Switzerland) · 2026Review
- Bioactive Materials and Novel Techniques in Endodontics: Translational Advances for Clinical Practice.Journal of functional biomaterials · 2026Article
- Cytotoxicity of Root Canal Sealers and Potential Clinical Implications: A Comprehensive Systematic Review of In Vitro Studies.Journal of clinical medicine · 2026Review
- Physical properties comparison of four bioceramic vs. epoxy resin-based root canal sealers: an in vitro study.BMC oral health · 2026Article
- Review
- Effect of dentine moisture conditions on interfacial adaptation of a calcium silicate-based sealer compared with an epoxy resin-based sealer: an SEM/EDX analysis.Biomaterial investigations in dentistry · 2026Article
- Article
- Comparative evaluation of apical micro leakage in root canals obturated with different bio ceramic sealers.Bioinformation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endodontic sealers are crucial for achieving an effective root canal obturation, preventing reinfection and promoting long-term treatment success. This review categorizes sealers by chemical composition, including traditional types such as zinc oxide-eugenol, glass ionomer, silicone, methacrylate and epoxy resins, calcium hydroxide, and the latest bioceramic formulations. Each type is evaluated for its physicochemical properties, biocompatibility, sealing ability, antimicrobial activity, and clinical limitations. A significant focus is placed on recent research into modifications of these materials with antimicrobial agents, aimed at improving antibacterial properties, bioactivity, and sealing performance. Among these, chitosan emerges as the most promising additive due to its broad antimicrobial spectrum, low cytotoxicity, and enhancement of sealing capacity. While bioceramic sealers represent a notable advancement due to their bioactivity and favorable interaction with moist environments, concerns regarding potential neurotoxicity and retreatability remain. The article presents recent advancements in the enhancement of endodontic sealers through the incorporation of organic and inorganic additives. It further delineates key research priorities, particularly the integration of bioactive materials, nanotechnology, and naturally derived compounds, with an emphasis on their potential applications in pediatric endodontics. Overall, while contemporary sealers offer a wide range of benefits, continued innovation is needed to optimize their biological safety, mechanical performance, and clinical usability.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.