Evidence map›Paper›PMID 41010040›Full record

ArticleGenes2025

Transcriptome of Sterile Testes in

Aleksei Krasnov, Sergey Afanasyev, Jens-Erik Dessen, Marianne H S Hansen, Marianne Vaadal, Helge Tveiten, Øivind Andersen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aleksei KrasnovThe Norwegian Institute of Aquaculture, Nofima, 9291 Tromsø, Norway.ORCID 0000-0002-1892-6333
Sergey AfanasyevSechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersburg 194233, Russia.
Jens-Erik DessenThe Norwegian Institute of Aquaculture, Nofima, 9291 Tromsø, Norway.ORCID 0000-0002-0667-4183
Marianne H S HansenThe Norwegian Institute of Aquaculture, Nofima, 9291 Tromsø, Norway.ORCID 0000-0001-6336-7908
Marianne VaadalThe Norwegian Institute of Aquaculture, Nofima, 9291 Tromsø, Norway.
Helge TveitenNorwegian College of Fishery Science, The Arctic University of Norway, 9019 Tromsø, Norway.
Øivind AndersenThe Norwegian Institute of Aquaculture, Nofima, 9291 Tromsø, Norway.

Funding

Institute of Evolutionary Physiology and Biochemistry Research Program № 075-00263-25-00Norwegian Seafood Research Fund's Project No. 901459
6 · The paper itself

Abstract

BACKGROUND/

objectivesInactivation of the

methodsAtlantic salmon with GC-ablated testes were produced by temporal silencing of

resultsIn sterile testes, transcripts of several GC markers were detected at low levels, suggesting the presence of cells with a GC-related expression profile that failed to initiate spermatogenesis. Expression of 260 genes was undetectable in the gonads of sterile males and females, and 61.5% of these were also inactivated during first maturation of fertile testes. This group was enriched with genes highly expressed in the brain, including those involved in endocrine and paracrine regulation, synaptic transmission, and numerous genes critical for brain development; among them, 45 genes encoding homeobox proteins. Another group of 229 genes showed increased expression in developing testes and included genes involved in neurosecretion and brain development regulation. GC-ablated testes showed increased expression of reproductive regulators such as

Indexed as

BrainFish ProteinsSalmo salarTestisTranscriptomeAnimalsFemaleGene Expression Regulation, DevelopmentalGonadsMaleSpermatogenesisFish ProteinsAtlantic salmondead endreprogrammingtestestranscriptome

Identifiers

PMID41010040
PMCPMC12469351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.