ArticleGenes2025
Identification of Key PANoptosis Regulators in Periodontitis and Chronic Obstructive Pulmonary Disease Using Gene Expression and Machine Learning Methods.
Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The role of programmed cell death in chronic obstructive pulmonary disease: from pathogenesis to treatment.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontitis (PD) is a chronic inflammatory disease associated with systemic conditions such as chronic obstructive pulmonary disease (COPD). PANoptosis-a form of regulated cell death integrating pyroptosis, apoptosis, and necroptosis-has been implicated in inflammatory diseases, but its role in PD and its overlap with COPD is not well understood.
methodsGene expression datasets for PD and COPD were retrieved from the Gene Expression Omnibus (GEO). Differentially expressed genes were intersected with 78 PANoptosis-related genes. Functional enrichment (GO, KEGG), protein-protein interaction (PPI) network analysis, and machine learning (XGBoost with ROC curves) identified key regulatory genes. Immune infiltration was evaluated, and drug-gene interactions were analyzed using DGIDB.
resultsSeven PANoptosis-related core genes-
conclusionsThis is the first study to link PANoptosis to both PD and COPD. The findings reveal shared molecular mechanisms and suggest PANoptosis-related genes as novel biomarkers and therapeutic targets in chronic inflammatory oral disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.