Evidence map›Paper›PMID 41009964›Full record

ArticleGenes2025

Identification of Novel Gene Cluster Potentially Associated with Insecticide Resistance in

Hyacinthe Dipina Ki, Mahamadi Kientega, Sabéré O G Yemien, Hamidou Maiga, Nouhoun Traoré, Koama Bayili, Moussa Namountougou, Abdoulaye Diabaté

Abstract read
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hyacinthe Dipina KiInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso 01 BP 545, Burkina Faso.ORCID 0009-0002-9782-071X
Mahamadi KientegaInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso 01 BP 545, Burkina Faso.ORCID 0000-0002-1715-8459
Sabéré O G YemienInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso 01 BP 545, Burkina Faso.
Hamidou MaigaInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso 01 BP 545, Burkina Faso.ORCID 0000-0001-8662-4700
Nouhoun TraoréInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso 01 BP 545, Burkina Faso.ORCID 0000-0002-6050-8717
Koama BayiliInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso 01 BP 545, Burkina Faso.
Moussa NamountougouUnité de Formation et de Recherche en Sciences de la Vie et de la Terre, Université Nazi Boni, Bobo-Dioulasso 01 BP 1091, Burkina Faso.
Abdoulaye DiabatéInstitut de Recherche en Sciences de la Santé (IRSS), Bobo-Dioulasso 01 BP 545, Burkina Faso.

Funding

Pan-African Mosquito Control Association OPP1214408Wellcome Trust
6 · The paper itself

Abstract

BACKGROUND/

objectivesDespite the increasing emergence of resistance, insecticide-based tools remain the primary method for malaria vector control in Africa. To maintain the effectiveness of these interventions, continuous monitoring and identification of novel resistance mechanisms is essential. This study aimed to investigate potential new insecticide resistance genes in the

methodsWe analyzed whole-genome sequencing data from the

resultsHigh haplotype homozygosity values, indicative of positive selection, were detected in a 2L chromosomal region corresponding to an aldehyde oxidase gene cluster (

conclusionsThis study provides evidence that aldehyde oxidase genes may contribute to insecticide resistance in POPULATIONS: These results highlight the importance of genomic surveillance for detecting novel resistance loci and guiding the development of improved vector control strategies under changing ecological and evolutionary conditions.

Indexed as

AnophelesInsecticide ResistanceInsect ProteinsMultigene FamilyAnimalsDNA Copy Number VariationsHaplotypesInsecticidesMalariaMosquito VectorsPolymorphism, Single NucleotideWhole Genome SequencingInsecticidesInsect Proteinsaldehyde oxidaseAn. gambiae s.l.genomic surveillanceinsecticide resistancemalaria

Identifiers

PMID41009964
PMCPMC12470184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.