Evidence map›Paper›PMID 41009953›Full record

ArticleGenes2025

Association Study of

Seong Shin Kwak, Ki Ook Lee, Chang Soo Ryu, Eun Ju Ko, Hyeon Woo Park, Jae Hyun Lee, Ok Joon Kim, Nam Keun Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seong Shin KwakDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.ORCID 0009-0002-4706-2463
Ki Ook LeeDepartment of Neurology, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea.
Chang Soo RyuDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.
Eun Ju KoDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.
Hyeon Woo ParkDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.
Jae Hyun LeeDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.
Ok Joon KimDepartment of Neurology, CHA Bundang Medical Center, School of Medicine, CHA University, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea.ORCID 0000-0002-7333-0647
Nam Keun KimDepartment of Life Science, Graduate School, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam 13488, Republic of Korea.ORCID 0000-0003-0541-3528

Funding

National Research Foundation of Korea 2022R1F1A1A1064169 and 2022R1F1A1076255
6 · The paper itself

Abstract

BACKGROUND/

objectivesStroke is a cerebrovascular disorder characterized by vessel occlusion or rupture, resulting in brain damage and subsequent physical impairment. Recent studies have implicated hevin-calcyon protein binding in the repair of brain injury. Secreted protein acidic and rich in cysteine-like 1 (

methodswe examined the associations of

resultsThe rs1049544 polymorphism was significantly associated with ischemic stroke prevalence (GG vs. CC: adjusted odds ratio [AOR] = 0.642,

conclusionsThese findings suggest that

Indexed as

Calcium-Binding ProteinsExtracellular Matrix ProteinsIschemic StrokePolymorphism, Single NucleotideAgedCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMaleMiddle AgedCalcium-Binding ProteinsExtracellular Matrix ProteinsSPARCL1 protein, humanhevin–calcyon bindingischemic strokepolymorphismSPARCL1

Identifiers

PMID41009953
PMCPMC12469447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.