Evidence map›Paper›PMID 41009891›Full record

ArticleAntibiotics (Basel, Switzerland)2025

Antibiotic Prescription Patterns in the Post-COVID-19 Era in Six European Countries: A Cross-Sectional Study.

Karel Kostev, Swati Upadhyaya, Oliver Utsch, Katarzyna Sosnowska, Marcel Konrad, Christian Tanislav

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Karel KostevPhilips University, University Hospital, 35043 Marburg, Germany.ORCID 0000-0002-2124-7227
Swati UpadhyayaConsulting, IQVIA, Bangalore 560103, India.ORCID 0009-0006-7039-5759
Oliver UtschOffering Development, IQVIA, 60549 Frankfurt am Main, Germany.ORCID 0009-0002-3494-6454
Katarzyna SosnowskaConsulting, IQVIA, 02-672 Warsaw, Poland.ORCID 0009-0001-5304-3050
Marcel KonradHealth & Social, FOM University of Applied Sciences for Economics and Management, 60486 Frankfurt am Main, Germany.ORCID 0000-0001-6798-5092
Christian TanislavDepartment of Geriatrics, Diakonie Hospital Jung Stilling Siegen, 57074 Siegen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveAfter the relaxation of acute containment measures during the COVID-19 pandemic, Europe experienced a substantial rebound of non-COVID infections surpassing pre-pandemic levels and causing significant clinical burden. The aim of our study is to analyze outpatient prescription data in Germany, France, Italy, Belgium, the UK, and Poland in order to assess trends and disparities in the post-COVID landscape.

methodsThe present cross-sectional study utilized data from six independently collected datasets containing details from longitudinal prescription (LRx) databases. We aimed to evaluate changes in the number of antibiotic prescriptions issued in 2022 (the first post-pandemic year) compared to 2021 (a pandemic year), as well as subsequent developments in 2023 and 2024. Analyses were stratified by age group and by sex. In addition, the most frequently prescribed antibiotics in each year and country were reported.

resultsAll countries experienced a marked increase in antibiotic use in 2022 compared to 2021. The year-on-year growth in 2022 ranged from +12.0% in France to a substantial +39.3% in Belgium. Germany, Poland, and the UK also showed strong increases of over 25%, while Italy rose by 21.5%. Growth slowed in 2023 and stabilized or declined in 2024, particularly in Poland, Italy, and Belgium. Pediatric antibiotic use surged in 2022, especially among children under 10 (+75% in the UK), then leveled off and even declined in some cases in 2024, while the number of antibiotic prescriptions in older adults either decreased or increased only slightly. Germany and the UK showed continued pediatric antibiotic use increases through 2023. Amoxicillin dominated prescriptions in most countries, but drug choice patterns varied widely by country.

conclusionsThis study shows a clear increase in outpatient antibiotic prescriptions issued across Europe after the COVID-19 pandemic, particularly among children and teenagers. Although the overall trends are now starting to level out, some countries still show rising numbers. These findings underscore the importance of a renewed focus on antibiotic stewardship programs, particularly in outpatient and primary care settings.

Indexed as

antibioticchildrenEuropeoutpatientspost-COVIDstewardship

Identifiers

PMID41009891
PMCPMC12466364

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.