ArticleAntibiotics (Basel, Switzerland)2025
In Vitro and In Silico Analysis of Differential Antibacterial Activity of Pomegranate Polyphenols Against Gram-Positive and Gram-Negative Bacteria.
Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Article
- Pomegranate (Veterinary sciences · 2026Review
- Active Biopolymeric Packaging for Fatty Foods: Chitosan/Electrospun Zein Bilayer Membranes with Natural Additive.ACS omega · 2026Article
- Phytochemical Diversity ofNutrients · 2026Review
- Chromatographic Determination and Antimicrobial Evaluation of Walnut (Plants (Basel, Switzerland) · 2026Article
- Multifunctional Finishing of Viscose Fabric with Pomegranate Peel Extract.Materials (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND/
objectivesThis study investigates the antimicrobial properties of pomegranate peel extract (PoPEx) and its major polyphenolic constituents against Gram-positive and Gram-negative bacteria, employing six clinical isolates of
methodsChemical composition was analyzed using liquid chromatography-mass spectrometry (LC-MS). Antimicrobial activity was determined by the broth microdilution method. Molecular docking was performed with the AutoDock Vina algorithm, and transport studies through porin channels were carried out using Caver software.
resultsPoPEx showed stronger activity against Gram-positive (MICs 15.62-500.00 μg/mL) than Gram-negative bacteria (MICs 125.00-500.00 μg/mL). Punicalagin was most active against
conclusionsLarger tannins exhibited strong target binding but limited porin permeability, reducing efficacy in Gram-negative bacteria. These findings provide insights into structure-activity relationships of pomegranate polyphenols and support their potential as natural antimicrobial agents.
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Registered trials
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