Evidence map›Paper›PMID 41009860›Full record

ArticleAntibiotics (Basel, Switzerland)2025

The Role of Surgical and Perioperative Factors in Shaping Gut Microbiome Recovery After Colorectal Surgery.

Julia Kohn, Alexander Troester, Zachary Ziegert, Julia Frebault, Sonja Boatman, Maria Martell, Harika Nalluri-Butz, Matthew C Bobel, Paolo Goffredo, Abigail J Johnson and 3 more

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

From gut dysbiosis to eubiosis: understanding microbiome recovery as an ecological process.Gut microbes · 2026
Review
Deciphering Post-surgery Gut Microbial Dynamics in Colorectal Cancer through Multi-cohort Machine Learning.Current microbiology · 2026
Article
SparCC co-occurrence networking reveals intracommunity dynamics of the microbiome following colorectal surgery.Microbiology spectrum · 2026
Article
The gut microbiome as a biomarker and modifiable risk factor in Lynch Syndrome.Familial cancer · 2026
Review
The gut microbiome in colorectal anastomotic leakage: from mechanisms to precision.Frontiers in medicine · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Julia KohnDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2266-5113

Alexander TroesterDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-9182-5814

Zachary ZiegertDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0001-7625-3800

Julia FrebaultDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0009-0006-3594-0686

Sonja BoatmanDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-1071-8249

Maria MartellDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-1150-8534

Harika Nalluri-ButzDivision of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN 55455, USA.

Matthew C BobelGranger Medical Center, 1250 E 3900 S #320, Salt Lake City, UT 84124, USA.ORCID 0000-0002-9027-1693

Paolo GoffredoDivision of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN 55455, USA.

Abigail J JohnsonSchool of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-5998-4724

Cyrus JahansouzDivision of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN 55455, USA.ORCID 0000-0002-7884-2799

Christopher StaleyDepartment of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-2309-0083

Wolfgang B GaertnerDivision of Colon and Rectal Surgery, Department of Surgery, University of Minnesota, 420 Delaware St. SE, Minneapolis, MN 55455, USA.

Funding

The Hubbard Foundation 21692

6 · The paper itself

Abstract

The gut microbiome is essential for gut health, immune regulation, and metabolism, but pathogenic bacteria like

methodsFecal samples were collected from patients undergoing colonoscopy (

resultsAlpha diversity (Shannon indices) decreased across all groups, recovering by POD10 in colonoscopy patients and by POD180 in non-resectional and resectional cohorts. Beta diversity (community composition) also returned to baseline by POD10 in colonoscopy patients and POD180 in non-resectional patients, but the resectional cohort did not fully recover (

conclusionsThese findings indicate that perioperative factors, especially surgical resection and SBP, significantly impact gut microbial recovery, with pathogenic bacteria persisting up to 6 months post-surgery.

Indexed as

antibioticsbowel preparationcolonoscopycolon surgerygut microbiotaIgAshort-chain fatty acids

Identifiers

PMID41009860

DOI10.3390/antibiotics14090881

PMCPMC12466354

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.