Evidence map›Paper›PMID 41009815›Full record

ReviewInternational journal of molecular sciences2025

Epigallocatechin-Gallate (EGCG): An Essential Molecule for Human Health and Well-Being.

Emanuele Rovaldi, Violante Di Donato, Giovanni Paolino, Marzia Bruno, Alessia Medei, Steven Paul Nisticò, Giovanni Pellacani, Norbert Kiss, Giulia Azzella, Andras Banvolgyi and 1 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emanuele RovaldiDermatology Unit, Department of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0009-0002-6432-8585
Violante Di DonatoDepartment of Obstetrics and Gynecology, University Sapienza of Roma, 00185 Rome, Italy.ORCID 0000-0002-9254-5790
Giovanni PaolinoUnit of Dermatology, IRCCS, Ospedale San Raffaele, 20132 Milano, Italy.
Marzia BrunoDermatology Unit, Department of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Alessia MedeiDepartment of Radiology, Ospedale Santa Maria, University Sapienza of Perugia, 05100 Terni, Italy.
Steven Paul NisticòDermatology Unit, Department of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0002-3828-0883
Giovanni PellacaniDermatology Unit, Department of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Norbert KissDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-9947-1755
Giulia AzzellaDermatology Unit, Department of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.
Andras BanvolgyiDepartment of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary.ORCID 0000-0002-7071-1364
Carmen CantisaniDermatology Unit, Department of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0003-2181-951X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Green tea, long consumed across Southeast Asia, is highly esteemed for its medicinal properties and is often favored over conventional treatments in Eastern cultures. Its health benefits are largely attributed to its minimal processing, which preserves pharmacologically active compounds, particularly catechins, a key class of polyphenols, with epigallocatechin-gallate (EGCG) being the most abundant and bioactive. These compounds exhibit antioxidant, anti-cancer, antimicrobial, and antiangiogenic properties. Beyond systemic health, EGCG has diverse applications in dermatology, including the treatment of viral warts, psoriasis, lichen sclerosus, acne, vaginal dryness, alopecia, and UV-induced skin damage. Emerging research also highlights its promise in aesthetic medicine for mitigating skin oxidative stress, improving skin brightness and neutralizing free radicals, responsible for wrinkles, hyperpigmentation, and loss of elasticity. The aim of this review is to examine the most recent literature on the wide-ranging clinical applications of Epigallocatechin-gallate (EGCG) and to assess its potential use as a daily foundational supplement to enhance both physical and mental well-being, focusing on the dermatological benefits.

Indexed as

AntioxidantsCatechinAnimalsHumansTeaAntioxidantsCatechinepigallocatechin gallateTeaagingcancercatechinflavonoidgreen teapolyphenols

Identifiers

PMID41009815
PMCPMC12470402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.