Evidence map›Paper›PMID 41009757›Full record

ArticleInternational journal of molecular sciences2025

Purified Native Collagen Extracellular Matrix Plus Polyhexamethylene Biguanide Functions as a Barrier to Protect Complex Wounds in an In Vivo Model.

Rami A Nasrallah, Kelly A Kimmerling, James L Cook, Chantelle C Bozynski, Aaron M Stoker, James P Stannard, Katie C Mowry

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rami A NasrallahOrganogenesis Innovation Center, San Diego, CA 92121, USA.ORCID 0009-0007-7859-3204
Kelly A KimmerlingOrganogenesis Discovery Center, Birmingham, AL 35243, USA.ORCID 0000-0002-3159-5700
James L CookThompson Laboratory for Regenerative Orthopaedics, Missouri Orthopaedic Institute, Columbia, MO 65212, USA.
Chantelle C BozynskiThompson Laboratory for Regenerative Orthopaedics, Missouri Orthopaedic Institute, Columbia, MO 65212, USA.ORCID 0000-0003-4755-867X
Aaron M StokerThompson Laboratory for Regenerative Orthopaedics, Missouri Orthopaedic Institute, Columbia, MO 65212, USA.
James P StannardThompson Laboratory for Regenerative Orthopaedics, Missouri Orthopaedic Institute, Columbia, MO 65212, USA.ORCID 0000-0001-8467-6494
Katie C MowryOrganogenesis Discovery Center, Birmingham, AL 35243, USA.ORCID 0000-0002-0047-544X

Funding

Organogenesis (United States) N/A
6 · The paper itself

Abstract

Complex surgical wounds often necessitate repeated irrigation and debridement (I&D), resulting in substantial burdens. Purified native collagen extracellular matrix plus polyhexamethylene biguanide (PCMP) is a protective antimicrobial barrier that supports innate wound healing and was hypothesized to protect an in vivo complex wound. Canines underwent bilateral fibular defects, which were stabilized using screws and plates pre-incubated with methicillin-resistant

Indexed as

BiguanidesCollagenExtracellular MatrixWound HealingAnimalsBiofilmsDisease Models, AnimalDogsMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsBiguanidesCollagenpolihexanidecomplex woundinfectionmethicillin-resistant Staphylococcus aureus (MRSA)polyhexamethylene biguanide (PHMB)purified native collagen extracellular matrix plus PHMB (PCMP)

Identifiers

PMID41009757
PMCPMC12470437

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.