Evidence map›Paper›PMID 41009725›Full record

ArticleInternational journal of molecular sciences2025

Bitter Taste Receptors TAS2R8 and TAS2R10 Reduce Proton Secretion and Differentially Modulate Cadmium Uptake in Immortalized Human Gastric Cells.

H Noreen Orth, Philip Pirkwieser, Maya Giridhar, Valerie Boger, Mark M Somoza, Andreas Dunkel, Veronika Somoza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

H Noreen OrthGraduate School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.
Philip PirkwieserLeibniz-Institute for Food Systems Biology at the Technical University of Munich, 85354 Freising, Germany.
Maya GiridharLeibniz-Institute for Food Systems Biology at the Technical University of Munich, 85354 Freising, Germany.
Valerie BogerLeibniz-Institute for Food Systems Biology at the Technical University of Munich, 85354 Freising, Germany.
Mark M SomozaLeibniz-Institute for Food Systems Biology at the Technical University of Munich, 85354 Freising, Germany.ORCID 0000-0002-8039-1341
Andreas DunkelLeibniz-Institute for Food Systems Biology at the Technical University of Munich, 85354 Freising, Germany.
Veronika SomozaLeibniz-Institute for Food Systems Biology at the Technical University of Munich, 85354 Freising, Germany.ORCID 0000-0003-2456-9245

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beyond sensing bitter-tasting compounds, bitter taste receptors (TAS2Rs) have been demonstrated to play a functional role in proton secretion as a key mechanism of gastric acid secretion (GAS) and the cellular uptake of the zinc metal ion. Given its chemical similarity and comparable effects in GAS, we focused this work on cadmium and hypothesized that gastric TAS2Rs are involved in (i) cadmium-induced inhibition of proton secretion and (ii) in its cellular uptake. To test this hypothesis, immortalized human parietal HGT-1 cells were exposed to 62.5-1000 µM CdCl

Indexed as

CadmiumParietal Cells, GastricReceptors, G-Protein-CoupledCell LineGastric AcidHumansProtonsTasteTaste Receptors, Type 2CadmiumProtonsReceptors, G-Protein-CoupledTaste Receptors, Type 2bitter taste receptorscadmiumcellular cadmium uptakemetal ion transporters

Identifiers

PMID41009725
PMCPMC12470311

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.