Evidence map›Paper›PMID 41009723›Full record

ReviewInternational journal of molecular sciences2025

Regulation of

Elizabeth Ruiz-Sánchez, Carolina Rojas, Petra Yescas Gómez, Nancy Martínez-Rodríguez, Ángel Alberto Ruiz-Chow, Concepción Nava-Ruiz, Gabriela Ibáñéz-Cervantes, Ivonne Maciel Arciniega-Martínez, Aldo Arturo Reséndiz-Albor, Patricia Rojas

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Neurodegenerative Disease: From Molecular Basis to Therapy, 3rd Edition.International journal of molecular sciences · 2026
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elizabeth Ruiz-SánchezLaboratorio de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez S.S., Avenida Insurgentes Sur. No. 3877, Mexico City 14269, Mexico.ORCID 0000-0002-8184-0532
Carolina RojasInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Circuito Escolar s/n, Mexico City 04510, Mexico.
Petra Yescas GómezDepartamento de Genética, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez S.S., Avenida Insurgentes Sur. No. 3877, Mexico City 14269, Mexico.
Nancy Martínez-RodríguezUnidad de Investigación Epidemiologica en Endocrinología y Nutrición, Hospital Infantil de México Federico Gómez, Dr Márquez 162, Mexico City 06720, Mexico.ORCID 0000-0002-7840-983X
Ángel Alberto Ruiz-ChowUnidad de Neuropsiquiatría, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez S.S., Avenida Insurgentes Sur. No. 3877, Mexico City 14269, Mexico.
Concepción Nava-RuizLaboratorio de Neuropatología Experimental, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez S.S., Avenida Insurgentes Sur. No. 3877, Mexico City 14269, Mexico.
Gabriela Ibáñéz-CervantesDepartamento de Desarrollo de Tecnologías, Centro Interdisciplinario de Ciencias Marinas (CICIMAR-IPN), Instituto Politécnico Nacional, C. Instituto Politécnico Nacional s/n, La Paz 23096, Baja California Sur, Mexico.ORCID 0000-0002-7969-0942
Ivonne Maciel Arciniega-MartínezLaboratorio de Inmunonutrición, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Mexico City 11340, Mexico.ORCID 0000-0001-5250-7952
Aldo Arturo Reséndiz-AlborLaboratorio de Inmunidad de Mucosas, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Mexico City 11340, Mexico.ORCID 0000-0003-1415-5524
Patricia RojasLaboratorio de Inmunidad de Mucosas, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Salvador Díaz Mirón s/n, Mexico City 11340, Mexico.ORCID 0000-0001-9079-3267

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear receptor subfamily 4 group A member 2 (NR4A2) is a transcription factor that regulates the expression of different genes involved in essential biological processes, including cell proliferation, neuronal development, immune response, cellular stress, apoptosis, DNA repair, and angiogenesis. The gene encoding this transcription factor is called NR4A2 and has been identified as an immediate early gene. Moreover, research in animal models and clinical trials has suggested an association between reduced

Indexed as

Gene Expression RegulationMental DisordersNeurodegenerative DiseasesNuclear Receptor Subfamily 4, Group A, Member 2AnimalsDNA MethylationEpigenesis, GeneticHumansNR4A2 protein, humanNuclear Receptor Subfamily 4, Group A, Member 2central nervous systemepigenetic mechanismsgene expression regulationneurodegenerative diseasesNR4A2 epigenetic mechanismsNR4A2 gene expressionpsychiatric disorderstranscription factors

Identifiers

PMID41009723
PMCPMC12471074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.