Evidence map›Paper›PMID 41009714›Full record

ArticleInternational journal of molecular sciences2025

Effect of Reoxygenation on Radioresistance of Chronically Hypoxic A549 Non-Small Cell Lung Cancer (NSCLC) Cells Following X-Ray and Carbon Ion Exposure.

Hasan Nisar, Bikash Konda, Marie Denise Hoffmann, Frederik M Labonté, Maryam Arif, Sebastian Diegeler, Claudia Schmitz, Christa Baumstark-Khan, François Chevalier, Christine E Hellweg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hasan NisarDepartment of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany.ORCID 0000-0001-5252-2212
Bikash KondaDepartment of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany.
Marie Denise HoffmannDepartment of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany.
Frederik M LabontéDepartment of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany.
Maryam ArifDepartment of Medical Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad 44000, Pakistan.
Sebastian DiegelerDepartment of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany.ORCID 0000-0003-3161-0744
Claudia SchmitzDepartment of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany.
Christa Baumstark-KhanDepartment of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany.
François ChevalierUniversité de Caen Normandie, ENSICAEN, CNRS, CEA, Normandie Université, CIMAP UMR6252, 14000 Caen, France.ORCID 0000-0002-8488-2324
Christine E HellwegDepartment of Radiation Biology, Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany.ORCID 0000-0002-2223-3580

Funding

European Union 262010 and 654002German Aerospace Center (DLR) FuW 475 Radiation & HypoxiaHigher Education Commission of Pakistan (HEC) - HRDI-UESTP's/UET's-Faculty Training in cooperation with the "Deutscher Akademischer Austauschdienst" - German Academic Exchange Service (DAAD) Ph.D. fellowship H.N.
6 · The paper itself

Abstract

Hypoxia-induced radioresistance in non-small cell lung cancer (NSCLC) hinders radiotherapy efficacy. Fractionated schedules exploit reoxygenation between fractions to reverse this resistance, but the effects of

Indexed as

CarbonCarcinoma, Non-Small-Cell LungLung NeoplasmsOxygenRadiation ToleranceA549 CellsCell HypoxiaCell SurvivalEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansInterleukin-6Interleukin-8X-RaysCarbonInterleukin-6Interleukin-8Oxygencell cycleDNA double-strand breaksDNA repairepithelial–mesenchymal transitionhypoxiainterleukin expressionionizing radiationlung cancernon-small cell lung cancer cellsradioresistancereoxygenationsurvival

Identifiers

PMID41009714
PMCPMC12470565

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.