Evidence map›Paper›PMID 41009702›Full record

ArticleInternational journal of molecular sciences2025

Mechanism of Regulation of NaCl Homeostasis in the Distal Colon During Obesity.

Balasubramanian Palaniappan, John Crutchley, Raja Singh Paulraj, Alip Borthakur, Subha Arthur

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Balasubramanian PalaniappanDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 27501, USA.ORCID 0000-0003-2082-7534
John CrutchleyMarshall Institute for Interdisciplinary Research, Marshall University, Huntington, WV 25703, USA.
Raja Singh PaulrajJoan C. Edwards School of Medicine, Marshall University, Huntington, WV 27501, USA.
Alip BorthakurDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 27501, USA.ORCID 0000-0002-5792-1279
Subha ArthurDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 27501, USA.

Funding

Regulation of Tight Junction Molecular Composition by Na/K-ATPaseP20GM121299 · NIGMS · MARSHALL UNIVERSITY · PI HAYNES, JENNIFER · 2018 to 2022
$10.6M
NIGMS NIH HHS P20 GM121299NIH HHS 5P20GM121299-05
6 · The paper itself

Abstract

Obesity is characterized by low-grade chronic inflammation, similar to the pathophysiology of inflammatory bowel disease (IBD) and colon cancer. IBD, which includes Crohn's disease and ulcerative colitis, is becoming increasingly common in obese individuals. Our previous research documented that both IBD and obesity involve disrupted NaCl homeostasis in the small intestine. The present study investigated how obesity affects NaCl homeostasis in the distal colon, using the Zucker (

Indexed as

ColonHomeostasisObesitySodium ChlorideAdenomaAnimalsChloride-Bicarbonate AntiportersColonic NeoplasmsInflammatory Bowel DiseasesMaleRatsRats, ZuckerChloride-Bicarbonate AntiportersSodium ChlorideCl−/HCO3− exchangercolonDownregulated in Adenoma (DRA)Na+/H+ exchangerobesity

Identifiers

PMID41009702
PMCPMC12470288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.