Evidence map›Paper›PMID 41009693›Full record

ArticleInternational journal of molecular sciences2025

N-Acetylchitooligosaccharides Alleviate Pulmonary Inflammation and Modulate Glycerophospholipid Metabolism in Murine Acute Lung Injury.

Xiongjie Sun, Fengnan Liu, Baifei Hu, Lin Zhu, Huabing Yang, Junping Zheng, Haiming Hu, Hongtao Liu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiongjie SunCollege of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China.
Fengnan LiuCollege of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China.
Baifei HuCollege of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China.ORCID 0000-0002-8006-4877
Lin ZhuCollege of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China.
Huabing YangCollege of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China.
Junping ZhengCollege of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China.
Haiming HuHubei Shizhen Laboratory, Wuhan 430061, China.ORCID 0000-0003-0089-457X
Hongtao LiuCollege of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China.ORCID 0000-0003-0149-6389

Funding

Hubei Provincial Joint Fund for Innovation and Development of Traditional Chinese Medicine NO. 2025AFD573Key Discipline Construction Project of Traditional Chinese Medicine in Hubei Province [2023] No.2, Febrile DiseasesSpecial Project of Hubei Provincial Technology Innovation Plan NO. 2023BCB033Special Scientific Research Projects for Double First-Class Construction of Hubei University of Chinese Medicine NO. 2023ZZXJB001
6 · The paper itself

Abstract

N-acetylchitooligosaccharides (NACOS) are functional oligosaccharides derived from shrimp and crab shells that exhibit a variety of biological activities. This study investigates the protective effects of NACOS against acute lung injury (ALI) induced by lipopolysaccharides (LPS) in mice and explores its underlying metabolic regulatory mechanisms. Histopathological analysis showed that NACOS reduced pulmonary inflammation, edema, and disruption of tight junctions in ALI mice. Molecular analysis indicated that NACOS downregulated key inflammatory mediators, including

Indexed as

Acute Lung InjuryChitinGlycerophospholipidsOligosaccharidesPneumoniaAnimalsDisease Models, AnimalLipopolysaccharidesMaleMetabolomicsMiceChitinGlycerophospholipidsLipopolysaccharidesOligosaccharidesglycerophospholipid metabolisminflammatory mediatorsmetabolic reprogrammingpulmonary inflammationuntargeted metabolomics

Identifiers

PMID41009693
PMCPMC12470115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.