Distinct Oxidative Stress Adaptations Driven by the Overexpression of miR-526b, miR-655, and COX-2 in Breast Cancer.

Reid M Opperman, Sujit Maiti, Mousumi Majumder

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Reid M OppermanDepartment of Biology, John R. Brodie Science Centre, Brandon University, 270 18th Street, Brandon, MB R7A6A9, Canada.

Sujit MaitiDepartment of Biology, John R. Brodie Science Centre, Brandon University, 270 18th Street, Brandon, MB R7A6A9, Canada.

Mousumi MajumderDepartment of Biology, John R. Brodie Science Centre, Brandon University, 270 18th Street, Brandon, MB R7A6A9, Canada.ORCID 0000-0003-0485-5172

Funding

BREAST CANCER CANADA 2022-004CANADA FOUNDATION FOR INNOVATION JOHN R. EVANS LEADER FUND 39674CANADA RESEARCH CHAIR PROGRAM 950 - 232738LOTTE AND JOHN HECHT MEMORIAL FOUNDATION 4885NATIONAL SCIENCE AND ENGINEERING RESEARCH COUNCIL OF CANADA RGPIN-2017-04787RESEARCH MANITOBA 4851

6 · The paper itself

Abstract

Oxidative stress has a dual role in breast cancer, promoting growth at moderate levels while causing cell death at higher levels, such as during therapeutic interventions that increase reactive oxygen species production. Oncogenic microRNAs miR-526b and miR-655 promote aggressive cancer traits-such as proliferation, migration, invasion, hypoxia response, cancer stem cell properties, and metastasis-via COX-2/EP4/PI3K pathways. These miRNAs and oxidative stress appear to engage in a self-amplifying loop, where miRNA overexpression increases ROS levels, and moderate oxidative stress, in turn, enhances miRNA expression-although the mechanisms are not yet fully understood. This study investigates how overexpressing miR-526b, miR-655, and COX-2 influences breast cancer cell responses to oxidative stress induced by H

Indexed as

Breast NeoplasmsCyclooxygenase 2MicroRNAsOxidative StressApoptosisCell Line, TumorCell SurvivalDNA DamageFemaleGene Expression Regulation, NeoplasticHumansHydrogen PeroxideMCF-7 CellsSignal TransductionCyclooxygenase 2Hydrogen PeroxideMicroRNAsPTGS2 protein, humanbreast cancercyclooxygenase-2 (COX-2)DNA damagehydrogen peroxidemicroRNAsmiR-526bmiR-655oxidative stressRNA-seq

Identifiers

PMID41009689

DOI10.3390/ijms26189103

PMCPMC12470079

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.