Evidence map›Paper›PMID 41009683›Full record

ArticleInternational journal of molecular sciences2025

Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases.

Panagiotis Lazanas, Charalabos Antonatos, Konstantina T Tsoumani, Argyro Sgourou, Yiannis Vasilopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Single-CellInternational journal of molecular sciences · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Panagiotis LazanasLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece.
Charalabos AntonatosLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-5967-9367
Konstantina T TsoumaniBiology Laboratory, School of Science and Technology, Hellenic Open University, 26504 Patras, Greece.
Argyro SgourouBiology Laboratory, School of Science and Technology, Hellenic Open University, 26504 Patras, Greece.ORCID 0000-0002-8299-3100
Yiannis VasilopoulosLaboratory of Genetics, Section of Genetics, Cell Biology and Development, Department of Biology, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-3167-7642

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis (AD) and autoimmune diseases exhibit epidemiological comorbidity, yet the shared genetic architecture remains incompletely understood. We investigated the genetic overlap between AD and three autoimmune disorders including inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and vitiligo, leveraging genome-wide association data. Despite modest evidence for global genetic correlations, we found 113 independent pleiotropic loci shared among AD and autoimmune diseases, with 11 displaying a concordant effect across all 3 pairwise comparisons. Gene-set and tissue enrichment analyses evidenced the inflammatory background of pleiotropic associations. Multi-trait colocalization analysis prioritized 22 loci, linking the tissue-specific expression of

Indexed as

Autoimmune DiseasesDermatitis, AtopicGenetic Predisposition to DiseaseArthritis, RheumatoidGenetic PleiotropyGenome-Wide Association StudyHumansInflammatory Bowel DiseasesMendelian Randomization AnalysisPolymorphism, Single NucleotideVitiligoatopic dermatitisinflammatory bowel diseasepleiotropyrheumatoid arthritisvitiligo

Identifiers

PMID41009683
PMCPMC12470386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.