Evidence map›Paper›PMID 41009682›Full record

ArticleInternational journal of molecular sciences2025

Pharmacokinetic Profiling Using

Miho Shimizu, Wataru Sugai, Eri Ohto-Fujita, Aya Atomi, Norio Nogawa, Koichi Takamiya, Hisao Yoshinaga, Yoshihide Asano, Takashi Yamashita, Shinichi Sato and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Miho ShimizuMaterial Health Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.ORCID 0000-0002-4149-6247
Wataru SugaiMaterial Health Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.
Eri Ohto-FujitaMaterial Health Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.
Aya AtomiMaterial Health Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.
Norio NogawaIsotope Science Center, The University of Tokyo, Tokyo 113-0032, Japan.
Koichi TakamiyaInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka 590-0494, Japan.ORCID 0009-0008-1205-3173
Hisao YoshinagaInstitute for Integrated Radiation and Nuclear Science, Kyoto University, Osaka 590-0494, Japan.
Yoshihide AsanoDepartment of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.ORCID 0000-0001-5560-9778
Takashi YamashitaDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Shinichi SatoDepartment of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Atsushi EnomotoRadiation Biology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Nozomi HatakeyamaMaterial Health Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.
Shunsuke YasudaMaterial Health Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.
Kazuya TanakaDepartment of Physical Therapy, Faculty of Medical Science, Teikyo University of Science, Yamanashi 409-0193, Japan.ORCID 0009-0007-7207-5895
Tomoaki AtomiPhysical Therapy Major, Department of Rehabilitation, Faculty of Health Sciences, Kyorin University, Tokyo 181-8612, Japan.ORCID 0000-0002-2568-9639
Kenji HaradaHealth Service Center, Tokyo University of Agriculture and Technology, Tokyo 183-8538, Japan.
Yukio HasebeAlmado Inc., Tokyo 103-0022, Japan.
Toshiyuki WatanabeDivision of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.ORCID 0000-0003-4555-0068
Yoriko AtomiMaterial Health Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.ORCID 0000-0003-3808-6543

Funding

Japan Society for the Promotion of Science JP 20K11620
6 · The paper itself

Abstract

Eggshell membrane (ESM) is composed of approximately 90% protein. Our previous studies in healthy adults demonstrated that two months of daily ESM intake improved respiratory function, zigzag walking speed, and skin elasticity. The present study aims to address the knowledge gap regarding the in vivo effects of ESM in the context of inflammatory bowel disease (IBD). Proteomic analysis was performed on powdered ESM used as a dietary supplement. To investigate its pharmacokinetics in mice, tritium (

Indexed as

ColitisEgg ShellGastrointestinal MicrobiomeMuramidaseAdministration, OralAdultAnimalsDextran SulfateDietary SupplementsDisease Models, AnimalFecesFemaleHumansMaleMiceMiddle AgedDextran SulfateMuramidaseBifidobacteriumdextran sulfate sodium (DSS) colitiseggshell membrane (ESM)gut microbiotainflammatory bowel disease (IBD)intestinal fibrosisLactobacillaleslysozyme (LYZ)

Identifiers

PMID41009682
PMCPMC12471195

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.