Evidence map›Paper›PMID 41009681›Full record

ArticleInternational journal of molecular sciences2025

Estrogens and Antioxidants Prevent the Formation of Tubular Aggregates in Aging Male Mice.

Giorgia Rastelli, Matteo Serano, Barbara Girolami, Alice Brasile, Vincenzo Sorrentino, Laura Pietrangelo, Feliciano Protasi

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giorgia RastelliCAST-Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.ORCID 0000-0002-2476-7519
Matteo SeranoMolecular Medicine Section, Department of Molecular and Developmental Medicine, University of Siena, I-53100 Siena, Italy.ORCID 0000-0002-4151-2980
Barbara GirolamiCAST-Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.
Alice BrasileCAST-Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.ORCID 0009-0002-5927-6995
Vincenzo SorrentinoMolecular Medicine Section, Department of Molecular and Developmental Medicine, University of Siena, I-53100 Siena, Italy.ORCID 0000-0002-8573-8631
Laura PietrangeloCAST-Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.ORCID 0000-0003-1197-7813
Feliciano ProtasiCAST-Center for Advanced Studies and Technology, University G. d'Annunzio of Chieti-Pescara, I-66100 Chieti, Italy.ORCID 0000-0002-0213-7591

Funding

Molecular Mechanism and Functional Role of SOCE in Skeletal MuscleR01AR059646 · NIAMS · UNIVERSITY OF ROCHESTER · PI DIRKSEN, ROBERT T · 2010 to 2020
$3.6M
Center for Gene Therapy and Drugs Based on RNA Technology, funded in the framework of the National Recovery and Resilience Plan (NRRP), M4C2 Inv, 1.4 - Spoke 1 to VS B63C22000610006Italian Telethon ONLUS to FP and VS GGP19231National Institutes of Health USA to FP subcontract of AR059646NIAMS NIH HHS R01 AR059646
6 · The paper itself

Abstract

Tubular aggregates (TAs), ordered arrays of sarcoplasmic reticulum (SR) tubes, are the main morphological alteration found in muscle biopsies from patients affected by TA myopathy (TAM). TAM has been linked to mutations in the genes encoding for STIM1 and ORAI1, which are two proteins that mediate Store-Operated Ca

Indexed as

AgingAntioxidantsEstrogensSarcoplasmic ReticulumAnimalsCalciumMaleMiceORAI1 ProteinOxidative StressStromal Interaction Molecule 1AntioxidantsCalciumEstrogensORAI1 ProteinStromal Interaction Molecule 1electron microscopysarcoplasmic reticulumskeletal musclestore-operated calcium entry

Identifiers

PMID41009681
PMCPMC12470441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.