Evidence map›Paper›PMID 41009678›Full record

ArticleInternational journal of molecular sciences2025

Apoptosis Inhibitor of Macrophage (AIM) Modulates Calcium Oxalate-Induced Ureteral Fibrosis in AIM-Felinized Mice.

Yuka Machida, Masaki Watanabe, Fumi Suzuki, Ryo Ando, Koudai Watanabe, Yugo Moriya, Kenichi Maeda, Shozo Okano, Tadashi Okamura, Ryoichi Sugisawa and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuka MachidaLaboratory of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
Masaki WatanabeLaboratory of Laboratory Animal Science, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
Fumi SuzukiLaboratory of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
Ryo AndoLaboratory of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.ORCID 0009-0001-5076-7184
Koudai WatanabeLaboratory of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
Yugo MoriyaLaboratory of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
Kenichi MaedaLaboratory of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
Shozo OkanoLaboratory of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.ORCID 0000-0002-4510-5397
Tadashi OkamuraDepartment of Laboratory Animal Medicine, National Institute of Global Health and Medicine, Japan Institute for Health and Security, Tokyo 162-8655, Japan.ORCID 0000-0001-8457-1561
Ryoichi SugisawaDepartment of Biochemistry, Kindai University Faculty of Medicine, Osaka 589-8511, Japan.ORCID 0000-0002-5912-5647
Nobuya SasakiLaboratory of Laboratory Animal Science, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.ORCID 0000-0002-7971-3024
Satomi IwaiLaboratory of Small Animal Surgery 2, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.ORCID 0000-0002-6837-3546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium oxalate (CaOx) stones account for 90% of uroliths in cats and contribute to ureteral inflammation and fibrosis, although the underlying mechanism remains unclear. Apoptosis inhibitor of macrophage (AIM) is known to play a protective role against tubular injury in feline kidney disease. This study investigated whether AIM contributes to ureteral fibrosis by using AIM-felinized mice subjected to CaOx bead-induced ureteral injury. Male C57BL/6 mice (

Indexed as

Calcium OxalateUreterAnimalsCatsDisease Models, AnimalFibrosisMaleMiceMice, Inbred C57BLMice, KnockoutUreteral ObstructionCalcium Oxalateapoptosis inhibitor of macrophagefeline ureteral obstructionmouse mode

Identifiers

PMID41009678
PMCPMC12471175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.