Evidence map›Paper›PMID 41009666›Full record

ArticleInternational journal of molecular sciences2025

Optimization of Gelatin-Based Scaffolds for Soft Tissue Regeneration: In Vitro and In Vivo Performance.

Zita Szűcs-Takács, Viktória Varga, Fanni Bán, Viktória Harcsa, Balázs Pinke, Róbert Várdai, Fatime Gajnut, Enikő Major, István Hornyák

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zita Szűcs-TakácsInstitute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.ORCID 0009-0008-4482-0760
Viktória VargaInstitute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.ORCID 0009-0005-8769-1653
Fanni BánInstitute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.
Viktória HarcsaInstitute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.
Balázs PinkeDepartment of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, 1111 Budapest, Hungary.
Róbert VárdaiLaboratory of Plastics and Rubber Technology, Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, 1111 Budapest, Hungary.ORCID 0000-0002-9031-6724
Fatime GajnutInstitute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.
Enikő MajorInstitute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.ORCID 0000-0001-5854-9395
István HornyákInstitute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary.ORCID 0000-0002-7183-8973

Funding

Innovation Staff Exchange Research Programme under grant agreement 824007The Central Library of Semmelweis Universitythe Hungarian National Research, Development and Innovation Office OTKA K-125174, K-139230, and PD-143327the iP-Osteo project funding from the European Union's HORIZON 2020 MSCA-RISE Marie Skłodowska-Curie Researchthe Ministry of Innovation and Technology of Hungary from the NRDI Fund ÚNKP-22-4-II-SE-17, 2020-1.1.6-JÖVO-2021-00010, 2020-1.1.6-JÖVO-2021-00013; RRF-2.1.2.-12-2022-0001, TKP2021-EGA-25, TKP2021-EGA-21, TKP2021- EGA-23) and EKÖP-2024-66The research was also supported by grants from the Scientific and Innovation Office of Semmelweis University The research was also supported by grants from the Scientific and Innovation Office of Semmelweis University
6 · The paper itself

Abstract

In this study, promising compositions of cross-linked gelatin-based scaffolds were tested in vitro and in vivo. Our aim was to utilize a solid matrix that is suitable for medical applications, and to be regulated as a medical device as a soft tissue implant. Three different cross-linkers were used in vitro, and the optimal composition was chosen for in vivo testing. The surfaces of the scaffolds were observed with SEM, and, in the case of divinyl sulfone (DVS), small cracks appeared, and the structure was rigid. With the use of poly(ethylene glycol) diglycidyl ether (PEGDE), the surface was found to be uneven, but generally, the appearance was similar in each case. The optimal scaffold contained 5

Indexed as

Epoxy ResinsGelatinNeovascularization, PhysiologicRegenerationSulfonesTissue ScaffoldsAnimalsButylene GlycolsConnective TissueExtracellular MatrixMiceMice, Inbred C57BLMicroscopy, Electron, Scanning1,4-bis(2,3-epoxypropoxy)butaneButylene Glycolsdivinyl sulfoneEpoxy ResinsGelatinQuetol 651Sulfonesbiomaterialscross-linked gelatinin vivo remodelingsoft tissue implant

Identifiers

PMID41009666
PMCPMC12470226

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.