Evidence map›Paper›PMID 41009663›Full record

ArticleInternational journal of molecular sciences2025

Dietary Mannan Oligosaccharides Enhance Lactational Performance, Nutrient Metabolism, Plasma Metabolomics, and Gut Microbiota in Dezhou Donkeys.

Tianzheng Wang, Yaru Wang, Pengshuai Li, Jiaxin Liu, Xinyi Mao, Zuowei Li, Zhangxinhan Wen, Yuhan Yin, Yan Li, Gang Lin and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tianzheng WangState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yaru WangState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0009-0001-0904-6617
Pengshuai LiState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Jiaxin LiuState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Xinyi MaoState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Zuowei LiState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Zhangxinhan WenState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yuhan YinState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yan LiCollege of Animal Sciences, Xinjiang Agricultural University, Urumqi 830052, China.ORCID 0000-0002-5191-027X
Gang LinInstitute of Quality Standards and Testing Technology for Agricultural Products, Chinese Academy of Agricultural Science, Beijing 100081, China.ORCID 0000-0003-4106-3107
Haihua ZhangHebei Key Laboratory of Specialty Animal Germplasm Resources Exploration and Innovation, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China.
Honglei QuState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Qiugang MaState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0000-0001-7260-3765
Shimeng HuangState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.

Funding

Modern Agricultural Industrial Technology System in Hebei Province HBCT2024280203National Key Research and Development Programs of China 2023YFD1302000
6 · The paper itself

Abstract

This study investigated the effects of dietary mannan oligosaccharide (MOS) supplementation on growth performance, serum biochemistry, metabolomic profiles, and fecal microbiota in lactating Dezhou donkeys. Sixteen healthy jennies and their foals were randomly allocated to a control group (MCON), a group receiving no MOS, or an MOS-supplemented group (MMO; 0.5 g/kg diet) for 60 days. Compared with the MCON group, the MMO group showed a mitigation of lactational weight reduction, improved serum protein profiles, and favorable modulation of lipid metabolism. Furthermore, serum metabolomic analysis revealed 102 differentially abundant metabolites, which were enriched in 17 KEGG pathways involved in energy metabolism, bile secretion, and anti-inflammatory signaling. Key metabolites such as L-4-Chlorotryptophan, Gly-Trp, and cholylthreonine indicated enhanced nutrient metabolism and gut barrier function. Moreover, MOS supplementation significantly increased alpha diversity of the gut microbiota, altered community composition, and promoted the abundance of beneficial genera, including Clostridium and Bacteroides. Collectively, these results demonstrate that MOS supplementation improves metabolic health, modulates immune and antioxidant responses, and fosters a beneficial gut microbial ecosystem in lactating donkeys, suggesting its potential as an effective prebiotic in equine nutrition.

Indexed as

EquidaeGastrointestinal MicrobiomeLactationMannansNutrientsOligosaccharidesAnimal FeedAnimalsDietary SupplementsFemaleMetabolomeMetabolomicsPrebioticsMannansNutrientsOligosaccharidesPrebioticsDezhou donkeygut microbiotalactationmannan oligosaccharidesserum metabolome

Identifiers

PMID41009663
PMCPMC12471093

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.