Evidence map›Paper›PMID 41009662›Full record

ArticleInternational journal of molecular sciences2025

ACE-Dependent Alzheimer's Disease: Circulating ACE Phenotypes in Heterozygous Carriers of Rare

Iaroslav V Mironenko, Olga V Kryukova, Anastasiia A Buianova, Alexey V Churov, Mikhail S Arbatsky, Alyona A Kubrikova, Yunna S Petrusenko, Zhanna A Repinskaia, Anna O Shmitko, Galit A Ilyina and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Iaroslav V MironenkoInstitute on Aging Research, Russian Clinical Research Center of Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 129226 Moscow, Russia.ORCID 0009-0003-4108-1214
Olga V KryukovaChemistry Faculty, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0009-0005-1051-1642
Anastasiia A BuianovaGenomics Laboratory, Pirogov Russian National Research Medical University, 117513 Moscow, Russia.ORCID 0000-0001-7894-9222
Alexey V ChurovInstitute on Aging Research, Russian Clinical Research Center of Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 129226 Moscow, Russia.ORCID 0000-0002-3920-7581
Mikhail S ArbatskyInstitute on Aging Research, Russian Clinical Research Center of Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 129226 Moscow, Russia.
Alyona A KubrikovaInstitute on Aging Research, Russian Clinical Research Center of Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 129226 Moscow, Russia.
Yunna S PetrusenkoBiotech Campus LLC, 117437 Moscow, Russia.ORCID 0009-0002-8318-5241
Zhanna A RepinskaiaGenomics Laboratory, Pirogov Russian National Research Medical University, 117513 Moscow, Russia.ORCID 0009-0007-4228-6114
Anna O ShmitkoGenomics Laboratory, Pirogov Russian National Research Medical University, 117513 Moscow, Russia.ORCID 0000-0001-5256-0892
Galit A IlyinaGenomics Laboratory, Pirogov Russian National Research Medical University, 117513 Moscow, Russia.
Olga A KostChemistry Faculty, M.V. Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-9665-0523
Steven M DudekDepartment of Medicine, Division of Pulmonary, Critical Care, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-5624-0714
Irina D StrazheskoInstitute on Aging Research, Russian Clinical Research Center of Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 129226 Moscow, Russia.
Ruslan I IsaevInstitute on Aging Research, Russian Clinical Research Center of Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 129226 Moscow, Russia.
Elen A MkhitaryanInstitute on Aging Research, Russian Clinical Research Center of Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 129226 Moscow, Russia.
Olga N TkachevaInstitute on Aging Research, Russian Clinical Research Center of Gerontology, Pirogov Russian National Research Medical University, Ministry of Healthcare of the Russian Federation, 129226 Moscow, Russia.
Denis V RebrikovCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, 117513 Moscow, Russia.ORCID 0000-0002-1884-1807
Sergei M DanilovDepartment of Medicine, Division of Pulmonary, Critical Care, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-6901-4545

Funding

Ministry of Healthcare of Russian Federation 125022602916-4Ministry of Science and Higher Education of the Russian Federation 075-15-2019-1789
6 · The paper itself

Abstract

Damaging mutations of the Angiotensin I-converting enzyme (ACE) that result in low ACE levels may increase the risk of developing late-onset Alzheimer's disease (AD)

Indexed as

Alzheimer DiseasePeptidyl-Dipeptidase AAdultAgedAged, 80 and overFemaleGenetic Predisposition to DiseaseHeterozygoteHumansMaleMiddle AgedMutationPhenotypeACE protein, humanPeptidyl-Dipeptidase AAlzheimer’s diseaseangiotensin I-converting enzymeblood ACEcatalytic propertiesconformational changesmutationsscreening

Identifiers

PMID41009662
PMCPMC12471119

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.