ArticleInternational journal of molecular sciences2025
CD163/CD63+ Monocyte-Derived DC Profiled in Tissue by Multi-Antigen Analysis (MAA) Discriminate Chronic Eczema and Psoriasis.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Psoriasis (Pso) is a chronic inflammatory skin disease with a genetic predisposition and an assumed autoimmune pathomechanism. Autoantigens, dendritic cells (DCs), and the TNF/IL23/Il17 axis are seemingly the main drivers of this process. However, the difference to other DC-driven immune processes, like in eczematic skin, is insufficiently understood. Multi-antigen analysis (MAA) allows the staining of tissue with 100 antigens and more and provides a deeper insight into pathological processes, using advanced imaging analysis and quantification of topographical allocated processes. Here we used this technology to assess and compare the skin immune infiltrations in Pso, chronic eczema, and healthy controls. Tissue samples from both skin diseases (
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