Evidence map›Paper›PMID 41009613›Full record

ArticleInternational journal of molecular sciences2025

Meriam Ben Youssef, Javier Chao-Pellicer, Eduardo Hernández-Álvarez, Amani Omrani, Ines Sifaoui, Hichem Sebai, Isabel L Bazzocchi, José E Piñero, Ignacio A Jiménez, Jacob Lorenzo-Morales

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meriam Ben YoussefInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 La Laguna, Santa Cruz de Tenerife, Spain.
Javier Chao-PellicerInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 La Laguna, Santa Cruz de Tenerife, Spain.
Eduardo Hernández-ÁlvarezInstituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain.ORCID 0000-0002-4306-2696
Amani OmraniInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 La Laguna, Santa Cruz de Tenerife, Spain.ORCID 0009-0001-6213-4835
Ines SifaouiInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 La Laguna, Santa Cruz de Tenerife, Spain.
Hichem SebaiLaboratory of Functional Physiology and Valorization of Bio-Resources, Higher Institute of Biotechnology of Beja, University of Jendouba, Beja 382-9000, Tunisia.ORCID 0000-0003-0131-1401
Isabel L BazzocchiInstituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain.
José E PiñeroInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 La Laguna, Santa Cruz de Tenerife, Spain.ORCID 0000-0001-6233-8224
Ignacio A JiménezInstituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, Avenida Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain.ORCID 0000-0002-0641-607X
Jacob Lorenzo-MoralesInstituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 La Laguna, Santa Cruz de Tenerife, Spain.

Funding

Cabildo Insular de Tenerife (project CC20230222, CABILDO.23, 2023-2028)Consorcio Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Infecciosas (CI-BERINFEC), Instituto de Salud Carlos III, Ministerio de Sanidad, Madrid, Spain , and by the Cabildo Insular de Tenerife (2023) (CB21/13/00100)La Caixa-CajaCanarias (grant 2022CLISA26)MePRAM project , Instituto de Salud Carlos III, Ministerio de Ciencia e Inno-vación, funded by Next Generation EU funds from the European Union through the Recovery and Resilience Facility (PMP22/00092)Spanish Government and FEDER, EU (project PID2022-136549OB-100, funded by MCIN/AEI/10.13039/501100011033)ULL-La Caixa Foundation-CajaCanarias Postdoctoral Fellowship Programme (2024)University of Jendouba and through doctoral mobility grants for cotutelle theses (ULL-Santander), by Fundación Canaria para el Control de las Enfermedades Tropicales , and the Acción Exterior programme of the Cabildo de Tenerife (FUNCCET)
6 · The paper itself

Abstract

Current therapies for Primary Amoebic Meningoencephalitis (PAM) present several limitations; consequently, there is an urgent need to develop new therapeutic agents. In this regard, we undertook bioassay-guided isolation of

Indexed as

AmebicidesMenthaNaegleria fowleriPlant ExtractsHumansPlant LeavesStructure-Activity RelationshipTriterpenesUrsolic AcidAmebicidesPlant ExtractsTriterpenesUrsolic Acidmechanism of actionMentha rotundifoliaPrimary Amoebic Meningoencephalitisstructure-activity relationshipursolic acid

Identifiers

PMID41009613
PMCPMC12470768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.