ArticleInternational journal of molecular sciences2025
Functional Recovery by Transplantation of Human iPSC-Derived A2B5 Positive Neural Progenitor Cell After Spinal Cord Injury in Mice.
Yiyan Zheng, Xiaohui Chen, Ping Bu, Haipeng Xue, Dong H Kim, Hongxia Zhou, Xugang Xia, Ying Liu, Qilin Cao
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In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Yiyan ZhengCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL 34987, USA.ORCID 0000-0003-1512-384X Xiaohui ChenCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL 34987, USA.ORCID 0000-0003-3723-513X Ping BuVivian L Smith Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0009-0003-4097-490X Haipeng XueCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL 34987, USA.
Dong H KimVivian L Smith Department of Neurosurgery, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Hongxia ZhouCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL 34987, USA.
Xugang XiaCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL 34987, USA.
Ying LiuCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL 34987, USA.ORCID 0000-0003-1875-8293 Qilin CaoCenter for Translational Science, Florida International University, 11350 SW Village Pkwy, Port St. Lucie, FL 34987, USA.ORCID 0009-0000-5572-3108 Funding
Reconnecting the injured cervical spinal cord by transplanted human iPSC-derived neural progenitorsR01NS110707 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, YING · 2019 to 2023
$1.7MCombinatory strategies to functional remyelination after spinal cord injuryR01NS061975 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CAO, QI LIN · 2008 to 2012
$1.6MCraig H Neilsen Foundation 385446NIH HHS 1R01NS099635-01NIH HHS 1R01NS110707-01NINDS NIH HHS R01 NS061975NINDS NIH HHS R01 NS110707United States Department of Defense HT9425-25-1-0376Wellcome Trust 338617
6 · The paper itselfAbstract
Human induced pluripotent stem cells (hiPSCs) hold great potential for patient-specific therapies. Transplantation of hiPSC-derived neural progenitor cells (NPCs) is a promising reparative strategy for spinal cord injury (SCI), but clinical translation requires efficient differentiation into desired neural lineages and purification before transplantation. Here, differentiated hiPSCs-reprogrammed from human skin fibroblasts using Sendai virus-mediated expression of OCT4, SOX2, KLF4, and C-MYC-into neural rosettes expressing SOX1 and PAX6, followed by neuronal precursors (β-tubulin III
Indexed as
Induced Pluripotent Stem CellsNeural Stem CellsRecovery of FunctionSpinal Cord InjuriesStem Cell TransplantationAnimalsCell DifferentiationDisease Models, AnimalHumansKruppel-Like Factor 4MiceMice, Inbred NODMice, SCIDNeuronsKLF4 protein, humanKlf4 protein, mouseKruppel-Like Factor 4hiPSCneural repairneural stem cellsspinal cord injurytransplantation
Identifiers
PMID41009511
PMCPMC12469384
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