Evidence map›Paper›PMID 41009506›Full record

ArticleInternational journal of molecular sciences2025

Biofilm Formation, c-di-GMP Production, and Antimicrobial Resistance in Staphylococcal Strains Isolated from Prosthetic Joint Infections: A Pilot Study in Total Hip and Knee Arthroplasty Patients.

Andrea Liberatore, Alessia Bertoldi, Alice Balboni, Liliana Gabrielli, Alessia Cantiani, Federica Lanna, Maria Sartori, Silvia Brogini, Gianluca Giavaresi, Tiziana Lazzarotto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrea LiberatoreMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-6755-1937
Alessia BertoldiMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-5929-2269
Alice BalboniMicrobiology, Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0009-0009-0075-5116
Liliana GabrielliMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0002-5994-4749
Alessia CantianiMicrobiology, Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0009-0007-0405-2739
Federica LannaMicrobiology, Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.ORCID 0009-0001-5588-9690
Maria SartoriSurgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0002-2123-9032
Silvia BroginiSurgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0002-1229-9367
Gianluca GiavaresiSurgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0001-7843-5969
Tiziana LazzarottoMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.ORCID 0000-0003-3093-363X

Funding

Ministero della Salute RF-2019-12370058.
6 · The paper itself

Abstract

Total joint arthroplasty (TJA) and total joint replacement (TJR) are effective treatments for end-stage osteoarthritis, but prosthetic joint infections (PJIs) remain a significant complication. These infections are often associated with bacteria that form biofilms, which contribute to their persistence and resistance to treatment. The aim of this study was to investigate the biofilm-forming ability, cyclic diguanylic acid (c-di-GMP) production, and the presence of biofilm-associated genes in

Indexed as

Arthroplasty, Replacement, HipArthroplasty, Replacement, KneeBiofilmsCyclic GMPDrug Resistance, BacterialProsthesis-Related InfectionsStaphylococcal InfectionsStaphylococcusStaphylococcus aureusAgedAnti-Bacterial AgentsFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedAnti-Bacterial Agentsbis(3',5')-cyclic diguanylic acidCyclic GMPantimicrobial resistancebiofilm formationc-di-GMPprosthetic joint infectionStaphylococcus aureus

Identifiers

PMID41009506
PMCPMC12469266

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.