Evidence map›Paper›PMID 41009480›Full record

ArticleInternational journal of molecular sciences2025

Sex-Specific Effects of

Cristina Agliardi, Franca Rosa Guerini, Milena Zanzottera, Elisabetta Bolognesi, Domenico Caputo, Elisabetta Groppo, Marco Rovaris, Mario Clerici

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cristina AgliardiIRCCS Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy.ORCID 0000-0003-2022-3386
Franca Rosa GueriniIRCCS Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy.ORCID 0000-0001-9461-5927
Milena ZanzotteraIRCCS Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy.
Elisabetta BolognesiIRCCS Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy.ORCID 0000-0001-5554-1697
Domenico CaputoIRCCS Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy.
Elisabetta GroppoIRCCS Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy.ORCID 0000-0003-1459-5618
Marco RovarisIRCCS Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy.ORCID 0000-0001-9691-1957
Mario ClericiIRCCS Fondazione Don Carlo Gnocchi ONLUS, Via Capecelatro 66, 20148 Milan, Italy.ORCID 0000-0001-5920-6191

Funding

Fondazione Romeo ed Enrica InvernizziItalian Ministry Of Health Ricerca Corrente 2025, RC2025Italian Ministry of University and Research National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006)
6 · The paper itself

Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system that affects young adults with different clinical phenotypes: relapsing-remitting MS (RR-MS), secondary progressive MS (SP-MS), and primary progressive MS (PP-MS). Aquaporin 4 (AQP4), a protein found in astrocytes, plays a crucial role in CNS functions. We investigated the possible association of three

Indexed as

Aquaporin 4Genetic Predisposition to DiseaseMultiple SclerosisPolymorphism, Single NucleotideAdultCase-Control StudiesFemaleGenotypeHaplotypesHumansMaleMiddle AgedSex FactorsAQP4 protein, humanAquaporin 4AQP4EDSSgendergeneticmultiple sclerosis (MS)outcomepolymorphismrehabilitationrelapsing–remittingSNP

Identifiers

PMID41009480
PMCPMC12469881

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.