ArticleInternational journal of molecular sciences2025
The Synergistic Effect of Polysaccharides and Silane Coupling Agents on the Properties of Calcium Phosphate-Based Bone Substitutes.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Special Issue "Bioceramics: Challenges and Medical Applications of Calcium-Phosphate-Based Biocompatible Ceramics".International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In this study, novel hybrid cementitious materials composed of calcium phosphates and polysaccharides were obtained and developed. Moreover, the impact of two distinct silane coupling agents-tetraethyl orthosilicate (TEOS) and 3-glycidoxypropyltrimethoxysilane (GPTMS)-on the physicochemical and biological properties of the resulting materials was systematically analyzed. Comprehensive assessments were conducted to evaluate the chemical and phase compositions (using XRF, XRD, FTIR), setting behavior, mechanical strength, microstructure (SEM), porosity, in vitro chemical stability, and biological performance of bone cements. Notably, the synergistic effect of polysaccharides and silane coupling agents significantly enhanced the compressive strength of the cements, increasing it to 19.34 MPa. Additionally, the integration of citrus pectin into the liquid phase, along with the inclusion of hybrid hydroxyapatite-chitosan granules, not only enabled the formation of materials with high surgical handiness but also improved the materials' physicochemical characteristics. The findings from this study emphasize the beneficial role of silane coupling agents in improving the properties of calcium phosphate-based bone substitutes. The developed materials demonstrate substantial potential for use in bone tissue engineering according to ISO 10993. However, further in vitro and in vivo studies are required to confirm their safety and effectiveness.
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Registered trials
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