Catalyst-Free Assembly of δ-Lactam-Based Hydrazide-Hydrazone Compounds from 3-Arylglutaconic Anhydrides and Aldazines.

Anna Ananeva, Elizaveta Karchuganova, Dar'ya Spiridonova, Grigory Kantin, Olga Bakulina

Abstract read

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Anna AnanevaDepartment of Medicinal Chemistry, Institute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.

Elizaveta KarchuganovaDepartment of Medicinal Chemistry, Institute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.

Dar'ya SpiridonovaDepartment of Medicinal Chemistry, Institute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.ORCID 0000-0003-2823-0986

Grigory KantinDepartment of Medicinal Chemistry, Institute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.ORCID 0000-0001-9141-680X

Olga BakulinaDepartment of Medicinal Chemistry, Institute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.ORCID 0000-0002-4930-0739

Funding

Russian Science Foundation 22-13-00005-P

6 · The paper itself

Abstract

A novel general approach to cyclic hydrazide-hydrazone compounds with a dihydropyridine-2-one core has been developed, involving annulation of symmetrical aldazines with 3-arylglutaconic anhydrides. This approach provides the benefits of straightforward and catalyst-free procedures, diastereoselectivity, and the ability to switch between two isomeric dihydropyridine-2-one cores based on the reaction temperature. Several post-modifications were performed on the side functional groups and the core to demonstrate the synthetic potential of the resulting products. This approach significantly expands the chemical diversity of medicinally relevant

Indexed as

AnhydridesHydrazinesHydrazonesLactamsCatalysisMolecular StructureStereoisomerismAnhydridesHydrazinesHydrazonesLactamsaldazineanhydrideannulationarylglutaconichydrazide–hydrazoneδ-lactam

Identifiers

PMID41009403

DOI10.3390/ijms26188834

PMCPMC12469989

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.