Evidence map›Paper›PMID 41009379›Full record

ArticleInternational journal of molecular sciences2025

Peripheral Blood Biomarkers Reveal Dysregulated Monoaminergic Pathways in Obsessive-Compulsive Disorder: A Transcriptional and Epigenetic Analysis.

Fabio Bellia, Nicolaja Girone, Beatrice Benatti, Matteo Vismara, Mauro Pettorruso, Giovanni Martinotti, Bernardo Dell'Osso, Claudio D'Addario, Mariangela Pucci

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fabio BelliaDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0002-8443-6084
Nicolaja GironeDepartment of Psychiatry, Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.
Beatrice BenattiDepartment of Psychiatry, Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.ORCID 0000-0003-0539-7150
Matteo VismaraDepartment of Psychiatry, Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.
Mauro PettorrusoDepartment of Neuroscience and Imaging, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.
Giovanni MartinottiDepartment of Neuroscience and Imaging, "G. D'Annunzio" University of Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-7292-2341
Bernardo Dell'OssoDepartment of Psychiatry, Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.
Claudio D'AddarioDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0002-1275-098X
Mariangela PucciDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0003-4657-6075

Funding

European Union - Next Generation EU - NRRP M6C2 - Investment 2.1 Enhancement and strengthening of biomedical research in the NHS PNRRMAD-2022-12376693
6 · The paper itself

Abstract

This study investigated the complexity of neurotransmitter-related gene regulation in peripheral blood mononuclear cells (PBMCs) of patients with obsessive-compulsive disorder (OCD), aiming to identify clinically relevant molecular markers. We analyzed three key genes:

Indexed as

BiomarkersEpigenesis, GeneticMonoamine OxidaseObsessive-Compulsive DisorderSerotonin Plasma Membrane Transport ProteinsAdultCatechol O-MethyltransferaseDNA MethylationFemaleHumansLeukocytes, MononuclearMaleMiddle AgedPromoter Regions, GeneticYoung AdultBiomarkersCatechol O-MethyltransferaseCOMT protein, humanMonoamine OxidaseSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanepigeneticsmonoaminergic neurotransmitterneuropsychiatricobsessive–compulsive disorderperipheral blood mononuclear cells

Identifiers

PMID41009379
PMCPMC12469943

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.