Evidence map›Paper›PMID 41009372›Full record

ArticleInternational journal of molecular sciences2025

Exosomal MicroRNA let-7 Modulates Lipid Metabolism and Inflammation in Foamy Macrophages of Chronic Obstructive Pulmonary Disease.

Miao-Hsi Hsieh, Ping-Fang Lai, Pei-Chi Chen, Xiao-Ling Liu, Wei-Leng Chen, Wen-Shuo Kuo, Shulhn-Der Wang, Hui-Fang Kao, Li-Jen Lin, Lawrence Shih-Hsin Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Exploring the Roles of Wnt Signaling Pathway and Non-Coding RNAs in COPD.International journal of chronic obstructive pulmonary disease · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Miao-Hsi HsiehResearch Center of Allergy, Immunology and Microbiome (A.I.M.), China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.
Ping-Fang LaiInstitute of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.
Pei-Chi ChenResearch Center of Allergy, Immunology and Microbiome (A.I.M.), China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.
Xiao-Ling LiuResearch Center of Allergy, Immunology and Microbiome (A.I.M.), China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.ORCID 0009-0000-3860-975X
Wei-Leng ChenResearch Center of Allergy, Immunology and Microbiome (A.I.M.), China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.ORCID 0009-0002-3544-3314
Wen-Shuo KuoResearch Center of Allergy, Immunology and Microbiome (A.I.M.), China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.
Shulhn-Der WangSchool of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
Hui-Fang KaoDepartment of Nursing, National Tainan Junior College of Nursing, Tainan 700007, Taiwan.
Li-Jen LinSchool of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0001-7914-9235
Lawrence Shih-Hsin WuResearch Center of Allergy, Immunology and Microbiome (A.I.M.), China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.ORCID 0000-0001-6275-8368
Jiu-Yao WangResearch Center of Allergy, Immunology and Microbiome (A.I.M.), China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.ORCID 0000-0003-4540-9822

Funding

China Medical University Hospital, Taichung, Taiwan DMR-112-043 and DMR-113-114National Science and Technology Council, Taipei, Taiwan MOST 110-2314-B-039 -056 -MY3 and NSTC 111-2113-M-039-003-MY2
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) involves persistent inflammation and dysregulated lipid metabolism, with foamy macrophages playing a central role in disease progression. Exosomes-vesicles transporting microRNAs (miRNAs)-mediate intercellular communication, but their contribution to foamy macrophage-driven COPD remains unclear. This study investigates the role of exosomal miRNAs, particularly let-7, in modulating lipid metabolism and inflammation in foamy macrophages. Bone marrow-derived macrophages (BMDMs) were treated with oxidized low-density lipoprotein (oxLDL) and lipopolysaccharide (LPS) to induce foamy macrophage formation. Exosomal miRNA profiles were analyzed, and the function of let-7c-3p was assessed via transfection. Foamy macrophages released significantly more exosomes (392.7 × 10

Indexed as

ExosomesFoam CellsInflammationLipid MetabolismMicroRNAsPulmonary Disease, Chronic ObstructiveAnimalsHumansLipoproteins, LDLMacrophagesMaleMiceMice, Inbred C57BLSignal TransductionLipoproteins, LDLMicroRNAsmirnlet7 microRNA, humanmirnlet7 microRNA, mouseoxidized low density lipoproteinCOPDexosomesfoamy macrophagesinflammationlet-7lipid metabolismmicroRNAPPAR/RXR

Identifiers

PMID41009372
PMCPMC12470005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.