Evidence map›Paper›PMID 41009336›Full record

Trial reportInternational journal of molecular sciences2025

Biochemical Fingerprint of Early Healing After Enamel Matrix Derivative Application Using a Flapless Approach: A Randomized Clinical Trial.

Federica Romano, Giacomo Baima, Morta Stasikelyte, Ahmad Bebars, Anna Brusamolin, Francesco Franco, Giovanni Nicolao Berta, Mario Aimetti

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Federica RomanoDepartment of Surgical Sciences, CIR Dental School, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-5172-299X
Giacomo BaimaDepartment of Surgical Sciences, CIR Dental School, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-9395-4967
Morta StasikelyteDepartment of Surgical Sciences, CIR Dental School, University of Turin, 10126 Turin, Italy.
Ahmad BebarsDepartment of Surgical Sciences, CIR Dental School, University of Turin, 10126 Turin, Italy.
Anna BrusamolinDepartment of Surgical Sciences, CIR Dental School, University of Turin, 10126 Turin, Italy.
Francesco FrancoDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.ORCID 0009-0005-8527-9980
Giovanni Nicolao BertaDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.ORCID 0000-0002-3263-9349
Mario AimettiDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the effect of enamel matrix derivatives (EMD) on the early healing biomarkers' expression following flapless treatment. Thirty-eight patients with residual deep intrabony defects after steps 1 and 2 of periodontal therapy were randomly assigned to the test (flapless with EMD) or control group (flapless alone). Periodontal parameters were recorded at baseline and 6 months after treatment. Gingival crevicular fluid (GCF) was collected at baseline and 2 weeks after treatment to quantify the levels of biomarkers related to epithelial healing (epidermal growth factor, EGF), connective tissue healing (matrix metalloproteinase-8 [MMP-8], fibroblast growth factor [FGF], transforming growth factor-β [TGF-β]), and bone formation (osteoprotegerin [OPG]). The test group showed a significant reduction in MMP-8 levels (

Indexed as

Dental Enamel ProteinsWound HealingAdultBiomarkersEpidermal Growth FactorFemaleFibroblast Growth FactorsGingival Crevicular FluidHumansMaleMatrix Metalloproteinase 8Middle AgedOsteoprotegerinBiomarkersDental Enamel Proteinsenamel matrix proteinsEpidermal Growth FactorFibroblast Growth FactorsMatrix Metalloproteinase 8Osteoprotegerinbiomarkersgingival crevicular fluidintrabony defectsminimally invasive non-surgical proceduresperiodontal regeneration

Identifiers

PMID41009336
PMCPMC12469984

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.