Evidence map›Paper›PMID 41009327›Full record

ArticleInternational journal of molecular sciences2025

Brønstead Acid-Catalyzed Regiodivergent Hydroindolation of Indoles: Temperature-Controlled Markovnikov and Anti-Markovnikov Addition.

Asaithampi Ganesan, Yong-Uk Kwon

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Asaithampi GanesanDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.ORCID 0000-0001-8873-7987
Yong-Uk KwonDepartment of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.ORCID 0009-0008-6427-9422

Funding

National Research Foundation of Korea RS-2022-NR074212
6 · The paper itself

Abstract

Brønsted acid-catalyzed, regiodivergent hydroindolation of indoles with terminal aryl alkynes was developed, affording bis(indolyl)alkanes in good to excellent yields. Systematic investigations revealed that temperature variation plays a key role in determining the regioselectivity of anti-Markovnikov and Markovnikov addition reactions. The reaction proceeds efficiently under transition metal-free conditions in an environmentally benign water/alcohol solvent system, using readily available and inexpensive

Indexed as

BenzenesulfonatesIndolesAlkynesCatalysisSolventsStereoisomerismTemperature4-toluenesulfonic acidAlkynesBenzenesulfonatesIndolesSolventsanti-Markovnikov additionbis(indolyl)alkanesBrønsted acidhydroindolationindoleMarkovnikov additionp-toluenesulfonic acid

Identifiers

PMID41009327
PMCPMC12469531

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.