Evidence map›Paper›PMID 41009023›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Inhibitory Infrared Light Attenuates Mitochondrial Hyperactivity and Accelerates Restoration of Mitochondrial Homeostasis in an Oxygen-Glucose Deprivation/Reoxygenation Model.

Lucynda Pham, Tasnim Arroum, Paul T Morse, Jamie Bell, Moh H Malek, Thomas H Sanderson, Maik Hüttemann

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucynda PhamCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.ORCID 0009-0008-0872-4843
Tasnim ArroumCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.ORCID 0009-0004-9644-3494
Paul T MorseCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0003-1530-1466
Jamie BellCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.
Moh H MalekDepartment of Health Care Sciences, Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Thomas H SandersonDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Maik HüttemannCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.ORCID 0000-0001-6310-7081

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
Development and Testing of LUCID: A Therapeutic Device for Brain Injury Following Infant Cardiac ArrestU44NS125160 · NINDS · MITOVATION, INC. · PI MAIK HUETTEMANN, Thomas Hudson Sanderson · 2022 to 2026
$3.6M
Non-invasive mitochondrial modulation therapy for ischemic strokeR01NS120322 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUETTEMANN, MAIK, SANDERSON, THOMAS HUDSON · 2021 to 2025
$2.3M
Non-invasive infrared light therapy and medical device to treat spinal cord injuryR01NS134695 · NINDS · WAYNE STATE UNIVERSITY · PI MAIK HUETTEMANN, Moh H. Malek · 2024 to 2026
$1.7M
Mitochondrial Modulation Therapy After Brain TraumaR01NS142271 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joseph Wider · 2025 to 2026
$1.2M
NCI NIH HHS P30 CA022453NIH HHS 1R01NS120322-24NIH HHS 1R01NS134695-24NIH HHS 1U44NS125160-24NINDS NIH HHS R01 NS120322NINDS NIH HHS R01 NS134695NINDS NIH HHS R01 NS142271NINDS NIH HHS U44 NS125160
6 · The paper itself

Abstract

Ischemia/reperfusion (I/R) injury following stroke results in increased neuronal cell death due to mitochondrial hyperactivity. Ischemia results in loss of regulatory phosphorylations on cytochrome

Indexed as

cytochrome c oxidaseischemia/reperfusion injurymitochondriamitochondrial membrane potentialnear-infrared lightphosphorylationsreactive oxygen species

Identifiers

PMID41009023
PMCPMC12466360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.