Evidence map›Paper›PMID 41009008›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Evaluation of Polyphenolic Compounds Common in Greek Medicinal Plants for Their Antioxidant Effects and Antiviral Activity Against Dengue and Yellow Fever Viruses.

Eirini Kyriakopoulou, Aliki Tsakni, Evangelos Korakidis, George Mpekoulis, Katerina I Kalliampakou, Monika Polanska, Jan F M Van Impe, Efstathia Tsakali, Dimitra Houhoula, Niki Vassilaki

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Anti-Open veterinary journal · 2026
    Article
  4. Antitumor-Directed Fractionation ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eirini KyriakopoulouLaboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.ORCID 0009-0001-0764-6256
Aliki TsakniDepartment of Food Science and Technology, Faculty of Food Sciences, University of West Attica, 12243 Athens, Greece.ORCID 0009-0002-3278-7461
Evangelos KorakidisLaboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.ORCID 0009-0003-1888-0798
George MpekoulisLaboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.ORCID 0000-0003-0043-7993
Katerina I KalliampakouLaboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.ORCID 0000-0001-5547-6864
Monika PolanskaBioTeC+, Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering, KU Leuven, 9000 Ghent, Belgium.
Jan F M Van ImpeBioTeC+, Chemical and Biochemical Process Technology and Control, Department of Chemical Engineering, KU Leuven, 9000 Ghent, Belgium.ORCID 0000-0002-5904-1638
Efstathia TsakaliDepartment of Food Science and Technology, Faculty of Food Sciences, University of West Attica, 12243 Athens, Greece.ORCID 0000-0001-5630-1572
Dimitra HouhoulaDepartment of Food Science and Technology, Faculty of Food Sciences, University of West Attica, 12243 Athens, Greece.ORCID 0000-0002-4692-2081
Niki VassilakiLaboratory of Molecular Virology, Hellenic Pasteur Institute, 11521 Athens, Greece.ORCID 0000-0001-7992-3438

Funding

Erasmus Mondus Joint Master Degree in Food Systems Engineering, Technology and Business 619864-EPP-1-2020-1-BE-EPPKA1-JMD-MOB
6 · The paper itself

Abstract

Polyphenolic compounds, commonly found in Greek medicinal plants, exhibit promising antiviral and antioxidant properties, making them potential candidates for therapeutic purposes. This study aims to evaluate the antiviral activity of nine selected polyphenols against Dengue virus (DENV) and Yellow Fever virus (YFV) life cycles, alongside their antioxidant capacity determined by the DPPH method and the ABTS assay, and their ability to inhibit DNA strand scission induced by peroxyl radicals. Kaempferol and caffeic acid demonstrated the most potent inhibitory effects on DENV genome replication, while coumaric acid blocked viral entry more effectively. Notably, among the nine compounds, kaempferol exhibited the strongest anti-DENV effect, especially at the level of virus-released infectivity, showing the lowest EC

Indexed as

antioxidant capacitydengue virusDNA scissionGreek medicinal plantspolyphenolsyellow fever virus

Identifiers

PMID41009008
PMCPMC12466706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.