ReviewAntioxidants (Basel, Switzerland)2025
Harnessing Mitochondrial Function for Post-Stroke Rehabilitation: Unlocking Antioxidant Power.
Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Zinc-polydopamine nanozyme promotes mitochondrial biogenesis and alleviates inflammation and muscle atrophy during the perioperative period of surgery.Journal of materials science. Materials in medicine · 2026Article
- Mitochondrial-neuroimmune interfaces in post-stroke spasticity: from acute brain injury to chronic motor phenotypes.Frontiers in neuroscience · 2026Review
- Ischemic stroke neuroprotection revisited: translational barriers and a phase-resolved, biomarker-anchored framework.Archives of pharmacal research · 2026Review
- Article
- Mitotherapy and the Possibility of Energetic Rescue in Evolving Brain Death.Iranian journal of pharmaceutical research : IJPRArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-stroke rehabilitation has evolved to encompass advanced approaches that aim to optimize recovery for ischemic stroke survivors. Despite this progress, recovery remains limited, partly due to persistent oxidative stress and mitochondrial dysfunction that contribute to neuronal and muscular impairment. One such promising avenue is the stimulation of antioxidant capacity and the enhancement of mitochondrial function. Mitochondria are crucial for energy production and neuroprotection, which are essential for neurorecovery. This review explores the mechanisms involved in the role of mitochondrial function and antioxidant therapies, focusing on motor recovery after ischemic stroke and "brain-muscle axis" interplay in post-stroke rehabilitation. A comprehensive synthesis of clinical trial data is provided, highlighting interventions targeting mitochondrial bioenergetics, redox regulation, and mitochondrial dynamics. Furthermore, the review delves into the potential of recent mitochondrial-targeted therapies as adjuncts to traditional rehabilitation techniques, providing a more holistic approach to recovery. Emerging evidence suggests these therapies can reduce oxidative injury and support neuroplasticity; however, translation into consistent clinical benefit remains uncertain due to heterogeneity in study designs, endpoints, and patient populations. By understanding and leveraging the dynamics of mitochondrial function, healthcare providers can significantly enhance the rehabilitation outcomes for people with a range of conditions, from musculoskeletal disorders to neurological impairments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.